Purpose:

The aim of this study is to examine the potential effect of cilostazol and inflammation on cognitive impairment after stroke in an Asian population.

Methods:

Forty-five patients with cognitive impairment after ischemic stroke using cilostazol were enrolled as the study group and 45 patients using aspirin or clopidogrel were enrolled as the control group. Neuropsychiatric assessments were administered at the start of the study and after 6 months. Multiple logistic regression analysis was used to estimate the association between the cognitive change and cilostazol use. Macrophage polarization were assessed using flow cytometry in 7 patients.

Results:

There were a significantly higher number of patients with peripheral arterial occlusive disease in the cilostazol group. No significant differences were observed in the cognitive change between the cilostazol and control groups. M1 macrophage subset increment were observed in the patient having a declined cognitive change.

Conclusion:

Cilostazol did not make a significant difference in cognitive change after ischemic stroke. M1 macrophage subset increment may indicate post stroke cognitive decline. Due to limited number of subjects, these findings should be examined further in large-scale randomized clinical trials.

中文翻译：

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西洛他唑和炎症在缺血性中风后认知障碍中的作用

 目的：

本研究的目的是探讨西洛他唑和炎症对亚洲人群中风后认知障碍的潜在影响。

 方法：

45例使用西洛他唑治疗的缺血性脑卒中后出现认知障碍的患者作为研究组，45例使用阿司匹林或氯吡格雷的患者作为对照组。在研究开始时和 6 个月后进行神经精神评估。使用多元逻辑回归分析来估计认知变化与西洛他唑使用之间的关联。使用流式细胞术对 7 名患者的巨噬细胞极化进行了评估。

 结果：

西洛他唑组患有外周动脉闭塞性疾病的患者数量显着增加。西洛他唑组和对照组之间的认知变化没有观察到显着差异。在认知变化下降的患者中观察到 M1 巨噬细胞亚群增加。

 结论：

西洛他唑对缺血性中风后的认知变化没有显着影响。 M1 巨噬细胞子集的增加可能表明中风后认知能力下降。由于受试者数量有限，这些发现应在大规模随机临床试验中进一步检验。