Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate local bone metabolism and metabolic functions. In addition, these factors can regulate global energy homeostasis by altering insulin sensitivity, feeding behavior, and adipocyte commitment. These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis, treatment, and prevention of metabolic diseases such as osteoporosis, obesity, and diabetes mellitus. In this review, we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.

骨的主要功能是作为整个身体的支撑框架，并且是钙稳态和造血功能的主要调节剂。最近，越来越多的研究表明骨作为内分泌器官的重要性，表明骨源性因子调节局部骨代谢和代谢功能。此外，这些因素可以通过改变胰岛素敏感性、进食行为和脂肪细胞承诺来调节整体能量稳态。这些发现可能为相关代谢性疾病提供新的病理机制，或用于骨质疏松、肥胖、糖尿病等代谢性疾病的诊断、治疗和预防。在这篇综述中，我们总结了骨和骨衍生因子对能量代谢的调节作用，并讨论了未来研究的方向。