Humoral immunity provides protection from pathogenic infection and is mediated by antibodies following the differentiation of naive B cells (nBs) to antibody-secreting cells (ASCs). This process requires substantial epigenetic and transcriptional rewiring to ultimately repress the nB program and replace it with one conducive to ASC physiology and function. Notably, these reprogramming events occur within the framework of cell division. Efforts to understand the relationship of cell division with reprogramming and ASC differentiation in vivo have uncovered the timing and scope of reprogramming, as well as key factors that influence these events. Herein, we discuss the unique physiology of ASC and how nBs undergo epigenetic and genome architectural reorganization to acquire the necessary functions to support antibody production. We also discuss the stage-wise manner in which reprogramming occurs across cell divisions and how key molecular determinants can influence B cell fate outcomes.

中文翻译：

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浆细胞的表观遗传基因调控


体液免疫可提供针对病原体感染的保护，并由幼稚 B 细胞 (nB) 分化为抗体分泌细胞 (ASC) 后的抗体介导。这一过程需要大量的表观遗传和转录重新布线，以最终抑制 nB 程序并用有利于 ASC 生理学和功能的程序取代它。值得注意的是，这些重编程事件发生在细胞分裂的框架内。为了了解体内细胞分裂与重编程和 ASC 分化之间的关系，我们发现了重编程的时间和范围，以及影响这些事件的关键因素。在这里，我们讨论了 ASC 独特的生理学，以及 nB 如何进行表观遗传和基因组结构重组以获得支持抗体生产所需的功能。我们还讨论了细胞分裂过程中重编程发生的分阶段方式，以及关键分子决定因素如何影响 B 细胞命运结果。