Introduction: Patients with dementia show reduced adaptive, behavioral, and physiological responses to environmental threats. Physical exercise is expected to delay brain aging, maintain cognitive function and, consequently, help dementia patients face threats and protect themselves skillfully. Methods: To confirm this, we aimed to investigate the effects of the shaking exercise on the avoidance function in the senescence-accelerated mouse-prone strain-10 (SAMP-10) model at the behavioral and tissue levels. SAMP-10 mice were randomized into 2 groups: a control group and a shaking group. The avoidance response (latency) of the mice was evaluated using a passive avoidance task. The degree of amygdala and hippocampal aging was evaluated based on the brain morphology. Subsequently, the association between avoidance response and the degree of amygdala-hippocampal aging was evaluated. Results: Regarding the passive avoidance task, the shaking group showed a longer latency period than the control group (p #x3c; 0.05), even and low intensity staining of ubiquitinated protein, and had a higher number of and larger neurons than those of the control group. The difference between the groups was more significant in the BA region of the amygdala and the CA1 region of the hippocampus (staining degree: p #x3c; 0.05, neuron size: p #x3c; 0.01, neuron counts: p #x3c; 0.01) than in other regions. Conclusions: The shaking exercise prevents nonfunctional protein (NFP) accumulation, neuron atrophy, and neuron loss; delays the aging of the amygdala and hippocampus; and maintains the function of the amygdala-hippocampal circuit. It thus enhances emotional processing and cognition functions, the memory of threats, the skillful confrontation of threats, and proper self-protection from danger.
Dement Geriatr Cogn Disord Extra 2021;11:114–121

中文翻译：

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通过安全可行的震动运动疗法维持 SAMP-10 小鼠的杏仁核-海马回路功能

简介：痴呆症患者对环境威胁的适应性、行为和生理反应均降低。体育锻炼有望延缓大脑衰老，维持认知功能，从而帮助痴呆症患者面对威胁并巧妙地保护自己。方法：为了证实这一点，我们旨在在行为和组织水平上研究摇动运动对衰老加速小鼠易感品系 10 (SAMP-10) 模型中回避功能的影响。SAMP-10 小鼠被随机分为 2 组：对照组和摇动组。使用被动回避任务评估小鼠的回避反应（潜伏期）。根据大脑形态评估杏仁核和海马的老化程度。随后，评估了回避反应与杏仁核-海马老化程度之间的关联。结果：关于被动回避任务，摇动组比对照组表现出更长的潜伏期（ p #x3c；0.05），泛素化蛋白染色均匀且低强度，并且具有比对照组更多和更大的神经元。控制组。组间差异在杏仁核 BA 区和海马 CA1 区更为显着（染色程度： p #x3c；0.05，神经元大小： p #x3c；0.01，神经元计数： p #x3c；0.01）比其他地区。结论：摇晃运动可以防止非功能性蛋白（NFP）积累、神经元萎缩和神经元损失；延缓杏仁核和海马体的衰老；并维持杏仁核-海马回路的功能。因此，它可以增强情绪处理和认知功能、威胁记忆、巧妙应对威胁以及免受危险的适当自我保护。
痴呆老年认知障碍额外 2021 年；11:114–121