Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a multisystem autoinflammatory disease due to an underlying plasma cell disorder that lacks a standard treatment strategy because of its rarity. We report a case of relapsed POEMS syndrome successfully treated with a second ambulatory autologous hematopoietic-cell transplantation (AHCT) after a daratumumab desensitization protocol performed during the coronavirus disease (COVID-19) pandemic in a patient with coexisting human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis infections. He is a 37-year old Latin-American male who had been treated with radiation, CyBorD regimen, AHCT and bortezomib therapy before being referred to our service. It was decided to administer daratumumab therapy and subsequently perform the transplant. Placement of central venous access, fluid infusion, conditioning regimen with melphalan and previously cryopreserved autograft infusion were carried out in an outpatient basis. Following second AHCT, the patient demonstrated clinical, VEGF, hematological response and remains SARS-CoV-2 infection-free and in POEMS remission with excellent quality-of-life at last follow up (6 months). We evidenced that thanks to an outpatient transplant program, the best therapeutic modalities can be offered to patients with hematologic malignancies in the context of present or future pandemics. Finally, high-complexity patients with HIV infection should have access to the same treatment strategies as non–infected patients. A second AHCT in the outpatient setting is feasible, safe and highly effective to treat patients with relapsed POEMS syndrome.

多发性神经病，器官肿大，内分泌病，单克隆丙种球蛋白病和皮肤变化（POEMS）综合征是一种多系统性自发性疾病，原因是潜在的浆细胞疾病，由于其稀有性而缺乏标准的治疗策略。我们报告了一例在冠状病毒病（COVID-19）大流行期间患有共存人类免疫缺陷病毒（HIV）的患者中进行了daratumumab脱敏方案后，第二次非卧床自体造血细胞移植（AHCT）成功治疗复发的POEMS综合征的病例，乙型肝炎病毒（HBV）和梅毒感染。他是一位37岁的拉丁美洲男性，在接受我们的服务之前已经接受了放射治疗，CyBorD方案，AHCT和硼替佐米治疗。决定进行daratumumab治疗，然后进行移植。在门诊患者中进行中心静脉通路的放置，液体输注，美法仑的调理方案以及先前低温保存的自体移植输液。在第二次AHCT之后，该患者表现出临床，VEGF，血液学反应，并保持SARS-CoV-2无感染，并且POEMS缓解，且末次随访（6个月）的生活质量极佳。我们证明了借助门诊移植计划，可以在当前或将来的大流行中为患有血液系统恶性肿瘤的患者提供最佳的治疗方式。最后，HIV感染的高复杂性患者应获得与未感染患者相同的治疗策略。在门诊设置第二个AHCT是可行的，