Although it is generally accepted that negative symptoms of schizophrenia are associated with larger lateral ventricles, this general assumption could not be validated in patients with primary negative symptoms. To elucidate this issue, we conducted a five-year longitudinal study, including deficit (n = 13) and non-deficit (n = 26) schizophrenia patients with healthy controls (n = 18). Analysis with linear mixed effects modeling showed that both the left and the right lateral ventricles of the deficit patients enlarged more than the non-deficit patients. Our results suggest that structural alterations in deficit patients might follow a different trajectory than those in non-deficit patients.

尽管通常认为精神分裂症的阴性症状与较大的侧脑室有关，但是这种一般性的假设不能在原发性阴性症状的患者中得到证实。为了阐明这一问题，我们进行了一项为期五年的纵向研究，包括 患有健康对照（n  = 18）的精神分裂症患者（n  = 13）和非赤字（n = 26 ）。线性混合效应模型的分析表明，赤字患者的左，右侧脑室均比非赤字患者的侧脑室增大。我们的结果表明，与非缺乏症患者相比，缺乏症患者的结构改变可能遵循不同的轨迹。