Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX,Cell Calcium

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Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX
Cell Calcium ( IF 4.3 ) Pub Date : 2021-05-19 , DOI: 10.1016/j.ceca.2021.102416
Essam A Assali ₁ , Israel Sekler ₁

Affiliation

NCLX, the mitochondrial Na⁺/Ca²⁺ transporter is a key player in Ca²⁺ signaling. However, its role in Na⁺ signaling is poorly understood. In this review we focus on Na⁺ signaling by NCLX, and discuss recent physiological and pathophysiological roles attributed to the Na⁺ influx into mitochondria.

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