Superfluous and damaged mitochondria need to be efficiently repaired or removed. Mitophagy is a selective type of autophagy that can engulf a portion of mitochondria within a double-membrane structure, called a mitophagosome, and deliver it to the vacuole for degradation. Mitophagy has significant physiological functions from yeast to human, and recent advances in yeast mitophagy shed light on the molecular mechanisms of mitophagy, especially the regulation of mitophagy induction. This review summarizes our current knowledge about yeast mitophagy and considers several unsolved questions, with a particular focus on Saccharomyces cerevisiae.

中文翻译：

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酵母线粒体自噬：未回答的问题

需要有效修复或去除多余和受损的线粒体。线粒体自噬是一种选择性类型的自噬，它可以吞噬双膜结构内的一部分线粒体，称为线粒体吞噬体，并将其输送到液泡进行降解。从酵母到人类，线粒体自噬具有重要的生理功能，酵母线粒体自噬的最新进展揭示了线粒体自噬的分子机制，特别是线粒体自噬诱导的调控。这篇综述总结了我们目前关于酵母线粒体自噬的知识，并考虑了几个未解决的问题，特别关注酿酒酵母。