Neurogenesis in the neonatal period involves the proliferation and differentiation of neuronal stem/progenitor cells and the establishment of synaptic connections. This process plays a critical role in determining the normal development and maturation of the brain throughout life. Exposure to certain physical or chemical factors during the perinatal period can lead to many neuropathological defects that cause high cognitive dysfunction and are accompanied by abnormal hippocampal neurogenesis and plasticity. As an endocrine disruptor, gossypol is generally known to exert detrimental effects in animals exposed under experimental conditions. However, it is unclear whether gossypol affects neurogenesis in the hippocampal dentate gyrus during early developmental stages.

中文翻译：

---

棉酚发育暴露后小鼠的神经炎症诱导和海马神经发生的改变。

新生儿期的神经发生涉及神经元干/祖细胞的增殖和分化以及突触连接的建立。这个过程在决定一生中大脑的正常发育和成熟中起着至关重要的作用。在围产期暴露于某些物理或化学因素会导致许多神经病理学缺陷，引起高度的认知功能障碍，并伴有异常的海马神经发生和可塑性。作为一种内分泌干扰物，棉酚通常会在实验条件下暴露的动物中产生有害作用。但是，尚不清楚棉酚是否会在发育的早期阶段影响海马齿状回的神经发生。