Psychological burden in patients with COVID-19 and their relatives 90 days after hospitalization: A prospective observational cohort study,Journal of Psychosomatic Research

当前位置： X-MOL 学术 › J. Psychosom. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Psychological burden in patients with COVID-19 and their relatives 90 days after hospitalization: A prospective observational cohort study
Journal of Psychosomatic Research ( IF 3.5 ) Pub Date : 2021-05-19 , DOI: 10.1016/j.jpsychores.2021.110526
Alessia Vincent ₁ , Katharina Beck ₂ , Christoph Becker ₃ , Samuel Zumbrunn ₂ , Maja Ramin-Wright ₂ , Tabita Urben ₂ , Adrian Quinto ₂ , Rainer Schaefert ₄ , Gunther Meinlschmidt ₅ , Jens Gaab ₆ , Thomas Reinhardt ₇ , Stefano Bassetti ₈ , Philipp Schuetz ₉ , Sabina Hunziker ₄

Affiliation

Medical Communication and Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland; Division of Clinical Psychology and Psychotherapy, Faculty of Psychology, University of Basel, Switzerland.
Medical Communication and Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland.
Medical Communication and Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland; Emergency Department, University Hospital Basel, Basel, Switzerland.
Medical Communication and Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland; Department for Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland; Medical Faculty of the University of Basel, Basel, Switzerland.
Department for Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland; Medical Faculty of the University of Basel, Basel, Switzerland; Division of Clinical Psychology and Cognitive Behavioural Therapy, International Psychoanalytic University, Berlin, Germany; Division of Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Basel, Switzerland.
Division of Clinical Psychology and Psychotherapy, Faculty of Psychology, University of Basel, Switzerland.
Human Resources & Leadership Development, University Hospital Basel, Basel, Switzerland.
Medical Faculty of the University of Basel, Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Medical Faculty of the University of Basel, Basel, Switzerland; Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland.

Objective

COVID-19 causes psychological distress for patients and their relatives at short term. However, little research addressed the longer-term psychological outcomes in this population. Therefore, we aimed to prospectively assess clinically relevant psychological distress in hospitalized patients with COVID-19 and their relatives 90 days after hospital discharge.

Methods

This exploratory, prospective, observational cohort study included consecutive adult patients hospitalized in two Swiss tertiary-care hospitals between March and June 2020 for confirmed COVID-19 and their relatives. The primary outcome was psychological distress defined as clinically relevant symptoms of anxiety and/or depression measured with the Hospital Anxiety and Depression Scale (HADS) 90 days after discharge.

Results

Clinically relevant psychological distress 90 days after hospital discharge was present in 23/108 patients (21.3%) and 22/120 relatives (18.3%). For patients, risk and protective factors associated with clinically relevant psychological distress included sociodemographic, illness-related, psychosocial, and hospital-related factors. A model including these factors showed good discrimination, with an area under the receiver-operating characteristic curve (AUC) of 0.84. For relatives, relevant risk factors were illness-related, psychosocial, and hospital-related factors. Resilience was negatively associated with anxiety and depression in both patients and relatives and regarding PTSD in relatives only.

Conclusion

COVID-19 is linked to clinically relevant psychological distress in a subgroup of patients and their relatives 90 days after hospitalization. If confirmed in an independent and larger patient cohort, knowledge about these potential risk and protective factors might help to develop preventive strategies.

中文翻译：

住院90天后COVID-19患者及其亲属的心理负担：一项前瞻性观察队列研究

客观的

COVID-19会在短期内给患者及其亲属带来心理困扰。但是，很少有研究针对该人群的长期心理结果。因此，我们旨在前瞻性评估出院后90天住院的COVID-19患者及其亲属的临床相关心理困扰。

方法

这项探索性，前瞻性，观察性队列研究包括2020年3月至2020年6月期间在瑞士两家三级医院住院的成年患者，这些患者中已确诊的COVID-19及其亲属。主要结局是心理困扰，定义为出院后90天使用医院焦虑和抑郁量表（HADS）进行测量的临床相关焦虑和/或抑郁症状。

结果

出院后90天临床相关的心理困扰发生在23/108例患者（21.3％）和22/120亲属（18.3％）中。对于患者，与临床相关的心理困扰相关的风险和保护因素包括社会人口统计学，疾病相关的，心理社会的和医院相关的因素。包含这些因素的模型显示出良好的辨别力，接收器工作特性曲线（AUC）下方的面积为0.84。对于亲戚，相关的危险因素是疾病相关的因素，社会心理因素和医院相关的因素。在患者和亲戚中，复原力与焦虑和抑郁相关，并且仅在亲戚中与PTSD相关。