ABSTRACT

The available findings on the association between iron status and risk of stroke remain controversial. We used multivariable logistic regression and restricted cubic spline models to explore the association between iron exposures and risk of stroke in the US National Health and Nutrition Examination Survey (NHANES 2007–2016, n = 24,627). A total of 941 (3.82%) stroke cases were identified in this study. In women, the ORs with 95% CIs of prevalence of stroke were 0.92 (0.65–1.28), 0.66 (0.44–0.98) and 0.72 (0.49–1.08) across quartiles 2–4 compared with quartile 1 of iron intake, respectively. An inverse and L-shaped association between iron intake and risk of stroke in women was observed, and the curve plateaued at 20 mg/day. However, neither serum iron concentrations nor iron intake were significantly associated with riskof stroke in men. Our study found that iron intake was inversely associated with risk of stroke in a sex-dependent fashion.

摘要

关于铁状态与卒中风险之间关联的现有研究结果仍存在争议。我们使用多变量逻辑回归和限制三次样条模型来探索美国国家健康和营养检查调查（NHANES 2007-2016，n= 24,627)。本研究共发现 941 例（3.82%）中风病例。在女性中，与铁摄入量的四分位数相比，卒中患病率 95% 的 OR 分别为 0.92 (0.65-1.28)、0.66 (0.44-0.98) 和 0.72 (0.49-1.08)，在 2-4 分位数之间。观察到铁摄入量与女性中风风险之间呈 L 型反向关联，曲线在 20 毫克/天时趋于平稳。然而，血清铁浓度和铁摄入量均与男性卒中风险无显着相关性。我们的研究发现，铁摄入量与中风风险呈负相关，且呈性别依赖性。