Bone metastasis ultimately occurs due to a complex multistep process, during which the interactions between cancer cells and bone microenvironment play important roles. Prior to colonization of the bone, cancer cells must succeed through a series of steps that will allow them to gain migratory and invasive properties; epithelial-to-mesenchymal transition (EMT) is known to be integral here. The aim of this study was to determine the effects of G protein subunit alpha Q (GNAQ) on the mechanisms underlying bone metastasis through EMT pathway.

中文翻译：

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GNAQ 敲低通过肺癌细胞的上皮-间质转化促进骨转移。


骨转移最终是由于一个复杂的多步骤过程而发生的，在此过程中癌细胞与骨微环境之间的相互作用发挥着重要作用。在骨骼定植之前，癌细胞必须成功通过一系列步骤，使它们能够获得迁移和侵袭特性；已知上皮-间质转化（EMT）在这里是不可或缺的。本研究的目的是确定 G 蛋白亚基 α Q (GNAQ) 通过 EMT 途径对骨转移机制的影响。