Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic mice; however, the role of the gut microbiota in ameliorating efficacy of QDMC remains unclear. We investigated the effect of QDMC on the gut microbiota in a type 2 diabetic aged mouse model that was administered a high-fat diet. Proinflammatory (TNF-α and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine levels in the fat were normalized via oral administration of QDMC, and relative abundances of Bacteroides, Butyricimonas, Ruminococcus, and Mucispirillum were simultaneously significantly increased. The abundance of these bacteria was correlated to the expression levels of cytokines. Our findings suggest that the immunomodulatory activity of QDMC is partly mediated by the altered gut microbiota composition.

中文翻译：

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通过基于芦荟凝胶的配方QDMC对脂肪中促炎和抗炎细胞因子的调节与肠道菌群的改变有关。

异常的炎症反应与肠道微生物营养不良密切相关。据报道，口服芦荟凝胶配方的Qmatrix-糖尿病-复合物（QDMC）可以改善2型糖尿病小鼠的炎症。然而，肠道菌群在改善QDMC功效中的作用尚不清楚。我们调查了QDMC对2型糖尿病老年小鼠模型中肠道微生物群的影响，该模型被给予高脂饮食。促炎（TNF-α和IL-6）和抗炎在脂肪（IL-4和IL-10）细胞因子的水平通过QDMC的口服给药，和相对丰度归一类杆菌，Butyricimonas，瘤胃球菌属，和Mucispirillum同时显着增加。这些细菌的丰度与细胞因子的表达水平相关。我们的发现表明，QDMC的免疫调节活性部分是由肠道菌群组成的改变介导的。