Objective:

No clear answer has yet been attained as to the influence of prenatal exposure to infection on autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), either alone or as co-occurring issues. The current study examined links between hospital-recorded and maternal-reported prenatal infections and ASD, ADHD, and co-occurring ASD and ADHD.

Methods:

Participants were n = 15,462 children and mother pairs from the Millennium Cohort Study (MCS), a population-representative UK sample.

Results:

Findings show associations between maternal-reported infections and ASD, and some evidence of links with ADHD and co-occurring ASD and ADHD. Hospital-recorded infections were not found to be associated with ASD, ADHD, or their co-occurrence. Agreement between hospital-recorded and maternal-reported infections was low, which may explain the discrepant findings.

Conclusion:

Prenatal maternal infections may be associated with increased odds of ASD and ADHD. Findings point to the importance of drawing on multiple sources of information when ascertaining prenatal infection status.

中文翻译：

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英国千年队列研究中的产前产妇感染和儿童神经发育：关注 ASD 和 ADHD

客观的：

关于产前感染对自闭症谱系障碍（ASD）和注意力缺陷/多动障碍（ADHD）的影响，无论是单独的还是同时发生的问题，目前还没有明确的答案。目前的研究检查了医院记录和母亲报告的产前感染与 ASD、ADHD 以及同时发生的 ASD 和 ADHD 之间的联系。

方法：

参与者是来自具有人口代表性的英国样本千年队列研究 (MCS) 的 n = 15,462 对儿童和母亲。

结果：

研究结果显示了母亲报告的感染与 ASD 之间的关联，以及与 ADHD 以及同时发生的 ASD 和 ADHD 相关的一些证据。未发现医院记录的感染与 ASD、ADHD 或其同时发生有关。医院记录的感染和产妇报告的感染之间的一致性很低，这可能解释了不一致的发现。

结论：

产前母体感染可能与 ASD 和 ADHD 的几率增加有关。研究结果表明在确定产前感染状况时利用多种信息来源的重要性。