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The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance
BioEssays ( IF 3.2 ) Pub Date : 2021-05-19 , DOI: 10.1002/bies.202000285 Jonas Muhr 1 , Daniel W Hagey 2
BioEssays ( IF 3.2 ) Pub Date : 2021-05-19 , DOI: 10.1002/bies.202000285 Jonas Muhr 1 , Daniel W Hagey 2
Affiliation
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Development and maintenance of diverse organ systems require context-specific regulation of stem cell behaviour. We hypothesize that this is achieved via reciprocal regulation between the cell cycle machinery and differentiation factors. This idea is supported by the parallel evolutionary emergence of differentiation pathways, cell cycle components and complex multicellularity. In addition, the activities of different cell cycle phases have been found to bias cells towards stem cell maintenance or differentiation. Finally, several direct mechanistic links between these two processes have been established. Here, we focus on interactions between cyclin-CDK complexes and differentiation regulators of the Notch pathway and Sox family of transcription factors within the context of pluripotent and neural stem cells. Thus, this hypothesis formalizes the links between these two processes as an integrated network. Since such factors are common to all stem cells, better understanding their interconnections will help to explain their behaviour in health and disease.
中文翻译：
作为整合过程的细胞周期和分化：细胞周期蛋白和 CDK 相互调节 Sox 和 Notch 以平衡干细胞维持
不同器官系统的发育和维持需要对干细胞行为进行特定的环境调节。我们假设这是通过细胞周期机制和分化因子之间的相互调节来实现的。这一想法得到了分化途径、细胞周期成分和复杂多细胞性的平行进化出现的支持。此外，已发现不同细胞周期阶段的活动使细胞偏向于干细胞维持或分化。最后，在这两个过程之间建立了几个直接的机械联系。在这里，我们专注于细胞周期蛋白-CDK 复合物与 Notch 通路的分化调节因子和多能干细胞和神经干细胞背景下的 Sox 转录因子家族之间的相互作用。因此，这一假设将这两个过程之间的联系正式化为一个集成网络。由于这些因素对所有干细胞都是共同的，更好地了解它们的相互联系将有助于解释它们在健康和疾病中的行为。
更新日期：2021-06-20
中文翻译：
作为整合过程的细胞周期和分化：细胞周期蛋白和 CDK 相互调节 Sox 和 Notch 以平衡干细胞维持
不同器官系统的发育和维持需要对干细胞行为进行特定的环境调节。我们假设这是通过细胞周期机制和分化因子之间的相互调节来实现的。这一想法得到了分化途径、细胞周期成分和复杂多细胞性的平行进化出现的支持。此外，已发现不同细胞周期阶段的活动使细胞偏向于干细胞维持或分化。最后，在这两个过程之间建立了几个直接的机械联系。在这里，我们专注于细胞周期蛋白-CDK 复合物与 Notch 通路的分化调节因子和多能干细胞和神经干细胞背景下的 Sox 转录因子家族之间的相互作用。因此，这一假设将这两个过程之间的联系正式化为一个集成网络。由于这些因素对所有干细胞都是共同的，更好地了解它们的相互联系将有助于解释它们在健康和疾病中的行为。
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