The skin is home to a collection of fibroblastic cell types from varying embryonic origins. These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an important area for cutaneous biology, wound repair and regenerative medicine. In this mini-review we discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin’s wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration. We outline how the development of single cell sequencing has led to our improved understanding of fibroblastic lineages at the molecular level and discuss existing challenges and future outlook on developing regenerative therapies that are based on this emerging field of eclectic fibroblasts.

皮肤是来自不同胚胎起源的成纤维细胞类型集合的家园。这些不同的成纤维细胞谱系显示出独特的遗传程序和体内职能。研究成纤维细胞的多样性正在成为皮肤生物学、伤口修复和再生医学的重要领域。在这篇小型综述中，我们讨论了成纤维细胞谱系的不同胚胎起源、微环境和转录组学特征，以及这些不同的谱系如何塑造皮肤在损伤深度、解剖位置和发育时间上的伤口反应，以促进疤痕或再生。我们概述了单细胞测序的发展如何使我们在分子水平上提高了对成纤维细胞谱系的理解，并讨论了基于这一新兴领域的折衷成纤维细胞开发再生疗法的现有挑战和未来展望。