We propose that fructose-1,6-bisphosphate (F-1,6-BP) promotes a feedback loop between phosphofructokinase-1 (PFK1), phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), and PFK2/PFKFB3, which enhances aerobic glycolysis and sustains effector T (T_eff) cell activation, while oxidative metabolism is concomitantly downregulated. This regulation, promoted by low citrate and mitochondrial ATP synthesis, also sustains the Warburg effect in cancer cells.

中文翻译：

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1,6-二磷酸果糖促进 T 细胞中的 PI3K 和糖酵解？

我们建议果糖-1,6-二磷酸 (F-1,6-BP) 促进磷酸果糖激酶-1 (PFK1)、磷脂酰肌醇-3-激酶/蛋白激酶 B (PI3K/Akt) 和 PFK2/PFKFB3 之间的反馈回路，它增强有氧糖酵解并维持效应 T (T _eff ) 细胞活化，同时氧化代谢随之下调。这种由低柠檬酸盐和线粒体 ATP 合成促进的调节也维持了癌细胞中的 Warburg 效应。