Individuals with Mast Cell Activation Syndrome (MCAS), a rare chronic disease, experience unpredictable physical symptoms and diagnostic challenges resulting in poor emotional states. The prevalence and correlates of depressive symptoms were examined among 125 participants who completed the CES-D and relevant instruments. The majority reported a clinically-significant level of depression which was especially common among younger participants and those who reported greater loneliness or more disease-specific stressors. Greater magnitude of depressive symptoms was associated with greater illness intrusiveness, less social support, and lower optimism. Results highlight the value of interventions targeting loneliness and stressors unique to this population.

肥大细胞激活综合症 (MCAS) 是一种罕见的慢性疾病，患有肥大细胞激活综合症 (MCAS) 的人会经历不可预测的身体症状和诊断挑战，导致情绪状态不佳。在 125 名完成 CES-D 和相关工具的参与者中检查了抑郁症状的患病率和相关性。大多数人报告了临床显着水平的抑郁症，这在年轻参与者和那些报告更孤独或更多疾病特异性压力源的人中尤其常见。抑郁症状越严重，疾病侵入性越大、社会支持越少、乐观情绪越低。结果凸显了针对该人群特有的孤独感和压力源的干预措施的价值。