Auxin signaling regulates growth and developmental processes in plants. The core of nuclear auxin signaling relies on just three components: TIR1/AFBs, Aux/IAAs, and ARFs. Each component is itself made up of several domains, all of which contribute to the regulation of auxin signaling. Studies of the structural aspects of these three core signaling components have deepened our understanding of auxin signaling dynamics and regulation. In addition to the structured domains of these components, intrinsically disordered regions within the proteins also impact auxin signaling outcomes. New research is beginning to uncover the role intrinsic disorder plays in auxin-regulated degradation and subcellular localization. Structured and intrinsically disordered domains affect auxin perception, protein degradation dynamics, and DNA binding. Taken together, subtle differences within the domains and motifs of each class of auxin signaling component affect signaling outcomes and specificity.

中文翻译：

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生长素信号传导的结构方面


生长素信号调节植物的生长和发育过程。核生长素信号传导的核心仅依赖于三个组件：TIR1/AFB、Aux/IAA 和 ARF。每个组件本身由多个结构域组成，所有这些结构域都有助于生长素信号传导的调节。对这三个核心信号成分结构方面的研究加深了我们对生长素信号动力学和调节的理解。除了这些成分的结构域之外，蛋白质内本质上无序的区域也会影响生长素信号转导结果。新的研究开始揭示内在紊乱在生长素调节的降解和亚细胞定位中的作用。结构化和本质上无序的结构域影响生长素感知、蛋白质降解动力学和 DNA 结合。总而言之，每类生长素信号成分的结构域和基序内的细微差异会影响信号传导结果和特异性。