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Coinfections with Respiratory Pathogens among COVID-19 Patients in Korea
Canadian Journal of Infectious Diseases and Medical Microbiology ( IF 2.6 ) Pub Date : 2021-05-18 , DOI: 10.1155/2021/6651045
Kyoung Ho Roh 1 , Yu Kyung Kim 2 , Shin-Woo Kim 3 , Eun-Rim Kang 1 , Yong-Jin Yang 1 , Sun-Kyung Jung 1 , Sun-Hwa Lee 1 , Nackmoon Sung 1
Affiliation  

The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in upper and lower respiratory specimens and coinfection with other respiratory pathogens in patients with coronavirus disease 2019 (COVID-19) was investigated. Study subjects (N = 342) were retrospectively enrolled after being confirmed as SARS-CoV-2 positive, and their nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and sputum specimens were restored for SARS-CoV-2 retesting and respiratory pathogen detection. The majority of the subjects (96.5%, N = 330) were confirmed as SARS-CoV-2 positive using NPS/OPS specimens. Among the COVID-19 patients (N = 342), 7.9% (N = 27) and 0.9% (N = 3) were coinfected with respiratory viruses and Mycoplasma pneumoniae, respectively, yielding an 8.8% (N = 30) overall respiratory pathogen coinfection rate. Of the respiratory virus coinfection cases (N = 27), 92.6% (N = 25) were coinfected with a single respiratory virus and 7.4% (N = 2) with two viruses (metapneumovirus/adenovirus and rhinovirus/bocavirus). No triple coinfections of other respiratory viruses or bacteria with SARS-CoV-2 were detected. Respiratory viruses coinfected in the patients with COVID-19 were as follows: rhinovirus (N = 7, 2.1%), respiratory syncytial virus A and B (N = 6, 1.8%), non-SARS-CoV-2 coronaviruses (229E, NL63, and OC43, N = 5, 1.5%), metapneumovirus (N = 4, 1.2%), influenza A (N = 3, 0.9%), adenovirus (N = 3, 0.9%), and bocavirus (N = 1, 0.3%). In conclusion, the diagnostic value of utilizing NPS/OPS specimens is excellent, and, as the first report in Korea, coinfection with respiratory pathogens was detected at a rate of 8.8% in patients with COVID-19.

中文翻译:

韩国COVID-19患者中呼吸道病原体的合并感染

研究了2019年冠状病毒病患者(COVID-19)中上下呼吸道标本中严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)的检测以及与其他呼吸道病原体的共感染。研究对象(N  = 342)被确认为SARS-CoV-2阳性后进行回顾性研究,并恢复其鼻咽拭子(NPS),口咽拭子(OPS)和痰标本以进行SARS-CoV-2复检和呼吸道病原体检测。 使用NPS / OPS标本确认了大多数受试者(96.5%,N = 330)为SARS-CoV-2阳性。在COVID-19患者中(N  = 342),分别为7.9%(N  = 27)和0.9%(N = 3)分别与呼吸道病毒和肺炎支原体同时感染, 总体呼吸道病原体合并感染率为8.8%(N = 30)。在呼吸道病毒合并感染病例(N  = 27)中,有92.6%(N  = 25)被单一呼吸道病毒同时感染,而7.4%(N  = 2)被两种病毒(间充质肺病毒/腺病毒和鼻病毒/博卡病毒)同时感染。未检测到其他呼吸道病毒或细菌与SARS-CoV-2的三重合并感染。COVID-19患者合并感染的呼吸道病毒如下:鼻病毒(N  = 7,2.1 %),呼吸道合胞病毒A和B(N = 6、1.8%),非SARS-CoV-2冠状病毒(229E,NL63和OC43,N  = 5、1.5 %),间质肺病毒(N  = 4、1.2 %),甲型流感(N  = 3、0.9% ),腺病毒(N  = 3,0.9%)和博卡病毒(N  = 1,0.3 %)。总之,利用NPS / OPS标本的诊断价值极佳,并且,作为韩国的第一篇报道,在COVID-19患者中,呼吸道病原体的合并感染检出率为8.8%。
更新日期:2021-05-18
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