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Enhancing Single-Molecule Fluorescence Spectroscopy with Simple and Robust Hybrid Nanoapertures
ACS Photonics ( IF 6.5 ) Pub Date : 2021-05-18 , DOI: 10.1021/acsphotonics.1c00045 Abhay Kotnala 1 , Hongru Ding 2 , Yuebing Zheng 1
ACS Photonics ( IF 6.5 ) Pub Date : 2021-05-18 , DOI: 10.1021/acsphotonics.1c00045 Abhay Kotnala 1 , Hongru Ding 2 , Yuebing Zheng 1
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Plasmonic nanoapertures have found exciting applications in optical sensing, spectroscopy, imaging, and nanomanipulation. The subdiffraction optical field localization, reduced detection volume (∼attoliters), and background-free operation make them particularly attractive for single-particle and single-molecule studies. However, in contrast to the high field enhancements by traditional “nanoantenna”-based structures, small field enhancement in conventional nanoapertures results in weak light–matter interactions and thus small enhancement of spectroscopic signals (such as fluorescence and Raman signals) of the analytes interacting with the nanoapertures. In this work, we propose a hybrid nanoaperture design termed “gold-nanoislands-embedded nanoaperture” (AuNIs-e-NA), which provides multiple electromagnetic “hotspots” within the nanoaperture to achieve field enhancements of up to 4000. The AuNIs-e-NA was able to improve the fluorescence signals by more than 2 orders of magnitude with respect to a conventional nanoaperture. With simple design and easy fabrication, along with strong signal enhancements and operability over variable light wavelengths and polarizations, the AuNIs-e-NA will serve as a robust platform for surface-enhanced optical sensing, imaging, and spectroscopy.
中文翻译：
用简单而可靠的混合纳米孔径增强单分子荧光光谱
等离子纳米孔径在光学传感、光谱学、成像和纳米操纵中发现了令人兴奋的应用。亚衍射光场定位、减少的检测体积（~attoliters）和无背景操作使它们对单粒子和单分子研究特别有吸引力。然而，与传统的基于“纳米天线”的结构的高场增强相比，传统纳米孔径中的小场增强导致光与物质的相互作用较弱，因此相互作用的分析物的光谱信号（例如荧光和拉曼信号）的增强很小与纳米孔径。在这项工作中，我们提出了一种混合纳米孔径设计，称为“gold-nanoislands-embedded nanoaperture”（AuNIs-e-NA），它在纳米孔径内提供了多个电磁“热点”，以实现高达 4000 的场增强。相对于传统的纳米孔径，AuNIs-e-NA 能够将荧光信号提高 2 个数量级以上。凭借简单的设计和易于制造，以及强大的信号增强和对可变光波长和偏振的可操作性，AuNIs-e-NA 将作为表面增强光学传感、成像和光谱学的强大平台。
更新日期：2021-06-17
中文翻译：
用简单而可靠的混合纳米孔径增强单分子荧光光谱
等离子纳米孔径在光学传感、光谱学、成像和纳米操纵中发现了令人兴奋的应用。亚衍射光场定位、减少的检测体积（~attoliters）和无背景操作使它们对单粒子和单分子研究特别有吸引力。然而，与传统的基于“纳米天线”的结构的高场增强相比，传统纳米孔径中的小场增强导致光与物质的相互作用较弱，因此相互作用的分析物的光谱信号（例如荧光和拉曼信号）的增强很小与纳米孔径。在这项工作中，我们提出了一种混合纳米孔径设计，称为“gold-nanoislands-embedded nanoaperture”（AuNIs-e-NA），它在纳米孔径内提供了多个电磁“热点”，以实现高达 4000 的场增强。相对于传统的纳米孔径，AuNIs-e-NA 能够将荧光信号提高 2 个数量级以上。凭借简单的设计和易于制造，以及强大的信号增强和对可变光波长和偏振的可操作性，AuNIs-e-NA 将作为表面增强光学传感、成像和光谱学的强大平台。
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