This article presents the numerical analysis of electromechanics of a red blood cell under electric field in a microchannel. We use 3-D computation to study the dielectrophoretic (DEP) characteristics of the cell subjected to electric field generated by parallel planar electrodes. The aim of this work is to investigate the variation in electric field frequency of the DEP force on the cell in different orientations and to clarify cell behavior during the transition between the positive and negative dielectrophoresis, which is important for on-chip cell manipulation. We use the boundary element method and apply the boundary condition of transmembrane potential on the cell membrane for calculation. The simulation results show that the DEP characteristics depend highly on the orientation and the position of the cell from electrode edge. The vertical and horizontal DEP forces change their directions at different values of field frequency. The re-orientation of red blood cells observed in the experiment is related to the calculated DEP behavior.

中文翻译：

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交流电场下红细胞的机电分析

本文介绍了在微通道中电场作用下的红细胞的机电数值分析。我们使用3-D计算来研究细胞受到平行平面电极产生的电场的介电泳（DEP）特性。这项工作的目的是研究DEP力在不同方向上作用于细胞上的电场频率变化，并弄清正负电泳之间的过渡过程中的细胞行为，这对片上细胞操作非常重要。我们使用边界元方法，并在细胞膜上应用跨膜电位的边界条件进行计算。仿真结果表明，DEP特性在很大程度上取决于电极边缘的电池方向和位置。垂直和水平DEP力会在不同的场频值处改变其方向。在实验中观察到的红细胞的重新定向与计算出的DEP行为有关。