The aim of this study was to investigate the effect of hydroxypropyl-β-cyclodextrin (HPβCD), widely used as a solubility enhancer, on liposomal formulations. To this end, HPβCD was added to fabricate liposomes during the hydration process, and their physicochemical properties were evaluated. The Fourier transform infrared and nuclear magnetic resonance spectra revealed that HPβCD could interact with the model drug, ceftazidime (CAZ), and with phosphatidylcholine, a main component of liposomes. This leads to a rapid release of CAZ depending on the concentration of HPβCD. Nanosized HPβCD-incorporated liposomes complied with Korsmeyer–Peppas kinetics, and the release of drug increased without significant changes in the release pattern. Our approach, which relied on supramolecule-related interactions, could provide new insights into other lipid-based formulations for accelerating drug-release properties.

本研究的目的是研究广泛用作溶解度增强剂的羟丙基-β-环糊精 (HPβCD) 对脂质体制剂的影响。为此，在水化过程中加入 HPβCD 来制备脂质体，并评估了它们的理化性质。傅里叶变换红外光谱和核磁共振光谱显示 HPβCD 可以与模型药物头孢他啶 (CAZ) 和磷脂酰胆碱（脂质体的主要成分）相互作用。这导致 CAZ 的快速释放取决于 HPβCD 的浓度。掺入纳米 HPβCD 的脂质体符合 Korsmeyer-Peppas 动力学，药物释放增加而释放模式没有显着变化。我们的方法依赖于超分子相关的相互作用，