ABSTRACT

A diverse array of studies has been devoted to understanding the neurochemical systems supporting responsiveness to hypnotic suggestions, with implications for experimental and clinical applications of hypnosis. However, this body of research has only rarely been integrated and critically evaluated and the prospects for the reliable pharmacological manipulation of hypnotic suggestibility remain poorly understood. Here we draw on pharmacological, genotyping, neuroimaging, and electrophysiological research to synthesize current knowledge regarding the potential role of multiple widely-studied neurochemicals in response to suggestion. Although we reveal multiple limitations with this body of evidence, we identify converging results implicating different neurochemical systems in response to hypnotic suggestion. We conclude by assessing the extent to which different results align or diverge and outline multiple avenues for future research. Elucidating the neurochemical systems underlying response to suggestion has the potential to significantly advance our understanding of suggestion.

摘要

各种各样的研究致力于了解支持对催眠建议的反应的神经化学系统，对催眠的实验和临床应用有影响。然而，这一系列研究很少被整合和批判性评估，并且对催眠暗示性的可靠药理学操作的前景仍然知之甚少。在这里，我们利用药理学、基因分型、神经影像学和电生理学研究来综合当前关于多种广泛研究的神经化学物质在响应建议时的潜在作用的知识。尽管我们揭示了这些证据的多重局限性，但我们确定了涉及催眠暗示的不同神经化学系统的收敛结果。最后，我们评估了不同结果的一致或分歧程度，并概述了未来研究的多种途径。阐明对建议作出反应的神经化学系统有可能显着提高我们对建议的理解。