Rapid Clearance of IR783 and Methyl-β-cyclodextrin Complex for Improved Tumor Imaging,Particle & Particle Systems Characterization

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Rapid Clearance of IR783 and Methyl-β-cyclodextrin Complex for Improved Tumor Imaging
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2021-05-17 , DOI: 10.1002/ppsc.202100068
Wonbong Lim ₁ , Gayoung Jo ₂ , Bo Young Lee ₂ , Min Ho Park _{3,

4} , Hoon Hyun ₂

Affiliation

Near-infrared (NIR) fluorescence cancer imaging with targeted NIR fluorophores holds considerable promise for accurate detection and cancer diagnosis. Among the various NIR heptamethine cyanine dyes reported previously, IR783 as a single small molecule has been widely used for tumor-targeted imaging without the additional conjugation of targeting moieties. Despite the potential advantages of IR783, the major problems, such as its non-specific uptake in normal tissues/organs and slow clearance, remain to be solved. A key determinant of sensitivity and detectability in tumor imaging is the improvement of the tumor-to-background ratio (TBR). Herein, a simple and effective supramolecular complex self-assembled from IR783 and methyl-β-cyclodextrin is developed to improve tumor imaging accompanied by rapid clearance from the body. The IR783-cyclodextrin complex allowed for rapid whole body biodistribution, which remarkably reduced non-specific background uptake, and thus increased the TBR value within 24 h post-injection. Therefore, this strategy is applicable in combination with many different types of carbocyanine dyes for improved tumor imaging.

中文翻译：

快速清除 IR783 和甲基-β-环糊精复合物以改善肿瘤成像

具有靶向 NIR 荧光团的近红外 (NIR) 荧光癌症成像对于准确检测和癌症诊断具有相当大的前景。在先前报道的各种 NIR 七甲炔花青染料中，IR783 作为单个小分子已广泛用于肿瘤靶向成像，而无需额外结合靶向部分。尽管 IR783 具有潜在优势，但其在正常组织/器官中的非特异性摄取和缓慢清除等主要问题仍有待解决。肿瘤成像灵敏度和可检测性的一个关键决定因素是提高肿瘤与背景比 (TBR)。在此，开发了一种由 IR783 和甲基-β-环糊精自组装的简单有效的超分子复合物，以改善肿瘤成像，并伴随着从体内的快速清除。IR783-环糊精复合物允许快速全身生物分布，显着降低非特异性背景吸收，从而增加注射后 24 小时内的 TBR 值。因此，该策略可与许多不同类型的碳菁染料结合使用，以改善肿瘤成像。

更新日期：2021-06-20

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