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Impact of Snoring on Telomere Shortening in Adolescents with Atopic Diseases
Genes ( IF 2.8 ) Pub Date : 2021-05-18 , DOI: 10.3390/genes12050766 Keith T S Tung 1 , Rosa S Wong 1 , Hing-Wai Tsang 1 , Gilbert T Chua 1 , Dicky Chan 1 , Kate C Chan 2 , Wilfred H S Wong 1 , Jason C Yam 3 , Marco Ho 1 , Clement C Tham 3 , Ian C K Wong 4, 5 , Godfrey C F Chan 1 , Patrick Ip 1
Genes ( IF 2.8 ) Pub Date : 2021-05-18 , DOI: 10.3390/genes12050766 Keith T S Tung 1 , Rosa S Wong 1 , Hing-Wai Tsang 1 , Gilbert T Chua 1 , Dicky Chan 1 , Kate C Chan 2 , Wilfred H S Wong 1 , Jason C Yam 3 , Marco Ho 1 , Clement C Tham 3 , Ian C K Wong 4, 5 , Godfrey C F Chan 1 , Patrick Ip 1
Affiliation
Atopic diseases can impose a significant burden on children and adolescents. Telomere length is a cellular marker of aging reflecting the impact of cumulative stress exposure on individual health. Since elevated oxidative stress and inflammation burden induced by chronic atopy and snoring may impact telomere length, this study aimed to investigate whether snoring would moderate the relationship between atopic diseases and telomere length in early adolescence. We surveyed 354 adolescents and their parents. Parents reported the adolescents’ history of atopic diseases, recent snoring history as well as other family sociodemographic characteristics. Buccal swab samples were also collected from the adolescents for telomere length determination. Independent and combined effects of atopic diseases and snoring on telomere length were examined. Among the surveyed adolescents, 174 were reported by parents to have atopic diseases (20 had asthma, 145 had allergic rhinitis, 53 had eczema, and 25 had food allergy). Shorter TL was found in participants with a history of snoring and atopic diseases (β = −0.34, p = 0.002) particularly for asthma (β = −0.21, p = 0.007) and allergic rhinitis (β = −0.22, p = 0.023). Our findings suggest that snoring in atopic patients has important implications for accelerated telomere shortening. Proper management of atopic symptoms at an early age is important for the alleviation of long-term health consequences at the cellular level.
中文翻译:
打鼾对特应性疾病青少年端粒缩短的影响
特应性疾病会给儿童和青少年带来沉重的负担。端粒长度是衰老的细胞标志,反映了累积压力暴露对个人健康的影响。由于慢性特应性和打鼾引起的氧化应激和炎症负荷升高可能会影响端粒长度,本研究旨在调查打鼾是否会减轻青春期早期特应性疾病与端粒长度之间的关系。我们调查了 354 名青少年及其父母。父母报告了青少年的特应性疾病史、近期打鼾史以及其他家庭社会人口学特征。还从青少年收集口腔拭子样本用于端粒长度测定。检查了特应性疾病和打鼾对端粒长度的独立和综合影响。在接受调查的青少年中,父母报告有 174 人患有特应性疾病(20 人患有哮喘,145 人患有过敏性鼻炎,53 人患有湿疹,25 人患有食物过敏)。在有打鼾和特应性疾病病史的参与者中发现了较短的 TL(β = -0.34,p = 0.002) 特别是对于哮喘 (β = -0.21, p = 0.007) 和过敏性鼻炎 (β = -0.22, p = 0.023)。我们的研究结果表明,特应性患者的打鼾对加速端粒缩短具有重要意义。在早期正确处理特应性症状对于缓解细胞水平的长期健康后果很重要。
更新日期:2021-05-18
中文翻译:
打鼾对特应性疾病青少年端粒缩短的影响
特应性疾病会给儿童和青少年带来沉重的负担。端粒长度是衰老的细胞标志,反映了累积压力暴露对个人健康的影响。由于慢性特应性和打鼾引起的氧化应激和炎症负荷升高可能会影响端粒长度,本研究旨在调查打鼾是否会减轻青春期早期特应性疾病与端粒长度之间的关系。我们调查了 354 名青少年及其父母。父母报告了青少年的特应性疾病史、近期打鼾史以及其他家庭社会人口学特征。还从青少年收集口腔拭子样本用于端粒长度测定。检查了特应性疾病和打鼾对端粒长度的独立和综合影响。在接受调查的青少年中,父母报告有 174 人患有特应性疾病(20 人患有哮喘,145 人患有过敏性鼻炎,53 人患有湿疹,25 人患有食物过敏)。在有打鼾和特应性疾病病史的参与者中发现了较短的 TL(β = -0.34,p = 0.002) 特别是对于哮喘 (β = -0.21, p = 0.007) 和过敏性鼻炎 (β = -0.22, p = 0.023)。我们的研究结果表明,特应性患者的打鼾对加速端粒缩短具有重要意义。在早期正确处理特应性症状对于缓解细胞水平的长期健康后果很重要。