Purpose

We hypothesized that due to its specific characteristics, the Casper^TM RX carotid stent (CP) might be particularly suitable for venous sinus stenting (VSS) in patients with idiopathic intracranial hypertension (IIH). To test this theory, we compared it to the commonly used Precise Pro RX^TM stent (PP).

Methods

A total of 15 patients with IIH (median age 28.7 years) were reviewed retrospectively. Technical aspects as well as periinterventional and postinterventional complication rates were examined in patients treated with CP (n = 10) and the PP (n = 5). Improvements in cerebrospinal fluid opening pressure (CSF OP), transstenotic pressure gradient (TSPG) and clinical symptoms were also assessed. Results are shown as percentages and respective P-values.

Results

Stent delivery was easier and more successful with the CP than the PP (difficult/failed stent delivery 0.0% versus 57.1%). No severe peri- or postinterventional complications or instances of in-stent thrombosis and/or stenosis were observed during follow-up. Improvement of CSF OP and TSPG immediately after VSS as well as at 6‑month follow-up were comparable between the CP and PP groups. Both groups showed substantial and similar decreases in intensity and frequency of headache. Almost all patients with other IIH-related symptoms showed either improvement or complete resolution of the symptoms after VSS. All patients who were available for interview (n = 12/15) reported a substantial improvement in quality of life.

Conclusion

A VSS using the CP seems to be safe and effective. The CP may reduce the risk of difficult or failed stent delivery in patients with challenging intracranial venous anatomy.

中文翻译：

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Casper 与精密支架治疗特发性颅内高压患者

目的

我们假设由于其特殊特性，Casper ^TM RX 颈动脉支架 (CP) 可能特别适用于特发性颅内高压 (IIH) 患者的静脉窦支架 (VSS)。为了验证这一理论，我们将其与常用的 Precise Pro RX ^TM支架 (PP) 进行了比较。

方法

回顾性分析了总共 15 名 IIH 患者（中位年龄 28.7 岁）。在接受 CP ( n  = 10) 和 PP ( n  = 5)治疗的患者中检查了技术方面以及介入前后和介入后并发症的发生率。还评估了脑脊液开放压力 (CSF OP)、经狭窄压力梯度 (TSPG) 和临床症状的改善。结果显示为百分比和各自的P值。

结果

与 PP 相比，CP 支架输送更容易且更成功（支架输送困难/失败 0.0% 对 57.1%）。随访期间未观察到严重的围手术期或介入后并发症或支架内血栓形成和/或狭窄的情况。CP 组和 PP 组在 VSS 后立即以及 6 个月随访时 CSF OP 和 TSPG 的改善具有可比性。两组的头痛强度和频率均显着降低且相似。几乎所有具有其他 IIH 相关症状的患者在 VSS 后都表现出症状的改善或完全消退。所有可以接受采访的患者（n  = 12/15）都报告说生活质量有了显着改善。

结论

使用 CP 的 VSS 似乎是安全有效的。对于颅内静脉解剖具有挑战性的患者，CP 可降低支架置入困难或失败的风险。