Our current understanding of the molecular mechanisms underlying activation of store-operated Ca²⁺ entry (SOCE) relies in large part on studies that modulate the expression of STIM1 and Orai1. Shen et al. present the first detailed study to address the dynamics and stoichiometry of endogenous STIM1 and Orai1. They argue for an active SOCE cluster centered around a single Orai1 channel per punctum linked to 12 STIM1 dimers, which could have significant implications on SOCE-dependent Ca²⁺ signaling.

中文翻译：

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本土 SOCE 综合体：小而强大？

我们目前对钙库操纵的Ca ²⁺内流激活(SOCE) 分子机制的理解在很大程度上依赖于调节STIM1 和Orai1 表达的研究。沉等人。提出了第一个详细研究来解决内源性 STIM1 和 Orai1 的动力学和化学计量。他们认为活跃的 SOCE 簇以每个泪点的单个 Orai1 通道为中心，与 12 个 STIM1 二聚体相连，这可能对 SOCE 依赖性 Ca ²⁺信号传导产生重大影响。