Obesity-related oxidation stress plays a key role in obesity complications; however, its relation to thyroid status is an area for further research. The study aimed to assess thyroid function in obese children and its relation to oxidative deoxyribonucleic acid (DNA) damage. Fifty obese and 40 normal weight children were included. Anthropometric measurement, lipid profile, thyroid function, anti-thyroglobulin antibody, thyroid peroxidase antibody, and 8-hydroxydeoxyguanosine serum level as marker of oxidative DNA damage were measured. Thirty-six percent of children with obesity have subclinical hypothyroidism. Central obesity but not oxidative DNA damage and lipid profile was significantly associated with subclinical hypothyroidism. Waist circumference > 97th centile increases the risk for subclinical hypothyroidism (odd ratio 10.82; confidence interval 95% 2.75–42.409; p-value<0.001). Central obesity represents a risk factor for subclinical hypothyroidism in obese children. Oxidation DNA damage did not show significant association with subclinical hypothyroidism.

中文翻译：

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肥胖儿童的氧化性DNA损伤和亚临床甲状腺功能减退症

肥胖相关的氧化应激在肥胖并发症中起关键作用。然而，它与甲状腺状态的关系是有待进一步研究的领域。该研究旨在评估肥胖儿童的甲状腺功能及其与氧化脱氧核糖核酸（DNA）损伤的关系。包括五十名肥胖儿童和40名体重正常的儿童。测量人体测量，脂质分布，甲状腺功能，抗甲状腺球蛋白抗体，甲状腺过氧化物酶抗体和8-羟基脱氧鸟苷血清水平，作为氧化性DNA损伤的标志物。肥胖儿童中有36％患有亚临床甲状腺功能减退症。中枢型肥胖与亚临床甲状腺功能减退显着相关，但不具有氧化性DNA损伤和脂质分布。腰围> 97分时，会增加亚临床甲状腺功能减退的风险（比值10.82；置信区间95％2.75–42.409；p值<0.001）。中型肥胖是肥胖儿童亚临床甲状腺功能减退的危险因素。氧化性DNA损伤与亚临床甲状腺功能减退没有显着相关性。