Cannabis use is growing domestically due to recent legalization in many jurisdictions. There are two main species of cannabis, Cannabis sativa and Cannabis indica, and thousands of different commercially available cannabis strains. Although there are multiple reports of cannabis allergy in the literature, to our knowledge, there is no prior published report of selective cannabis strain allergy. A 31-year-old male was referred for allergy assessment due to several episodes of localized pruritus and erythema after direct contact with various strains of cannabis. He had noted that the severity of his reaction appeared to be strain dependent. He developed a severe local reaction involving bilateral periorbital edema shortly after coming into direct contact with one particular strain of cannabis. He denied any adverse symptoms after inhalation of cannabis. Fresh skin prick testing was performed to various strains of cannabis and had positive testing to the three of the five tested strains. We believe this is the first reported case of selective cannabis strain allergy based on patient history and skin prick testing. This case report outlines the variability in different strains of cannabis and stresses the importance of further research into cannabis allergen identification. Multiple cannabis allergens should be included and incorporated into commercial extracts when they become routinely available.

中文翻译：

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表现出局部过敏反应的患者的选择性大麻应变过敏

由于最近许多司法管辖区合法化，大麻的使用在国内正在增长。大麻有两种主要种类，即大麻和印度大麻，还有成千上万种不同的商业大麻菌株。尽管在文献中有关于大麻过敏的报道，但据我们所知，目前尚无关于选择性大麻毒株过敏的公开报道。一名31岁的男性因直接接触各种大麻菌株后出现几次局部瘙痒和红斑而被引荐进行过敏评估。他指出，他的反应的严重程度似乎与应变有关。直接接触一种特定的大麻后不久，他就出现了严重的局部反应，涉及双侧眼眶水肿。吸入大麻后，他否认有任何不良症状。对各种大麻菌株进行了新鲜的皮肤点刺测试，并对五种测试菌株中的三种进行了阳性测试。我们认为这是根据患者病史和皮肤点刺试验首次报告的选择性大麻菌株过敏案例。该病例报告概述了不同菌株的大麻的变异性，并强调了进一步研究大麻过敏原鉴定的重要性。常规使用时，应包括多种大麻过敏原并将其掺入商业提取物中。我们认为这是根据患者病史和皮肤点刺试验首次报告的选择性大麻菌株过敏案例。该病例报告概述了不同菌株的大麻的变异性，并强调了进一步研究大麻过敏原鉴定的重要性。常规使用时，应包括多种大麻过敏原并将其掺入商业提取物中。我们认为这是根据患者病史和皮肤点刺试验首次报告的选择性大麻菌株过敏案例。该病例报告概述了不同菌株的大麻的变异性，并强调了进一步研究大麻过敏原鉴定的重要性。常规使用时，应包括多种大麻过敏原并将其掺入商业提取物中。