A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4-dihydropyridine compounds. A number of aromatic aldehydes, ethylaceto acetate and urea converted into corresponding in l,4-Dihydropyridine derivatives via one-pot multicomponent reaction in sub-critical ethanol. This study shown that 1,4-dihyropyridines can be synthesized in sub-critical ethanol and has the advantage of excellent yields, short reaction time, and simple work-up conditions.

中文翻译：

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在亚临界乙醇中通过多组分反应高效绿色合成 1,4-二氢吡啶衍生物

已开发出一种简单、环保且高效的合成 1,4-二氢吡啶化合物的方法。许多芳香醛、乙酸乙酯和尿素通过一锅多组分反应在亚临界乙醇中转化为相应的 l,4-二氢吡啶衍生物。该研究表明，1,4-二氢吡啶可以在亚临界乙醇中合成，具有收率高、反应时间短和后处理条件简单等优点。