The prevalence of neurodegenerative disorders demands methods of accessible assessment that reliably captures cognition in daily life contexts. We investigated the feasibility of smartphone cognitive assessment in people with Parkinson’s disease (PD), who may have cognitive impairment in addition to motor-related problems that limit attending in-person clinics. We examined how daily-life factors predicted smartphone cognitive performance and examined the convergent validity of smartphone assessment with traditional neuropsychological tests.

Twenty-seven nondemented individuals with mild–moderate PD attended one in-lab session and responded to smartphone notifications over 10 days. The smartphone app queried participants 5x/day about their location, mood, alertness, exercise, and medication state and administered mobile games of working memory and executive function.

Response rate to prompts was high, demonstrating feasibility of the approach. Between-subject reliability was high on both cognitive games. Within-subject variability was higher for working memory than executive function. Strong convergent validity was seen between traditional tests and smartphone working memory but not executive function, reflecting the latter’s ceiling effects. Participants performed better on mobile working memory tasks when at home and after recent exercise. Less self-reported daytime sleepiness and lower PD symptom burden predicted a stronger association between later time of day and higher smartphone test performance.

These findings support feasibility and validity of repeat smartphone assessments of cognition and provide preliminary evidence of the effects of context on cognitive variability in PD. Further development of this accessible assessment method could increase sensitivity and specificity regarding daily cognitive dysfunction for PD and other clinical populations.

神经退行性疾病的流行需要一种易于使用的评估方法，能够可靠地捕捉日常生活环境中的认知。我们研究了智能手机认知评估对帕金森病 (PD) 患者的可行性，这些患者除了因运动相关问题而无法就诊之外，还可能存在认知障碍。我们研究了日常生活因素如何预测智能手机的认知表现，并研究了智能手机评估与传统神经心理学测试的收敛有效性。

27 名患有轻度至中度 PD 的非痴呆患者参加了一次实验室会议，并在 10 天内对智能手机通知做出了回应。该智能手机应用程序每天向参与者询问 5 次关于他们的位置、情绪、警觉性、锻炼和药物状态的信息，并管理工作记忆和执行功能的手机游戏。

对提示的响应率很高，证明了该方法的可行性。两种认知游戏的受试者间可靠性都很高。工作记忆的受试者内变异性高于执行功能。传统测试和智能手机工作记忆之间存在很强的收敛效度，但执行功能则不然，反映了后者的天花板效应。参与者在家中和最近锻炼后在移动工作记忆任务上表现更好。自我报告的白天嗜睡程度较低和 PD 症状负担较低，预示着一天中晚些时候与较高的智能手机测试表现之间存在更强的关联。

这些发现支持重复智能手机认知评估的可行性和有效性，并提供了环境对帕金森病认知变异性影响的初步证据。这种易于使用的评估方法的进一步发展可以提高帕金森病和其他临床人群日常认知功能障碍的敏感性和特异性。