The aim of this study was to examine the sociodemographic and clinical differences between people with a probable diagnosis of panic disorder (PD) and those with PD and a probable comorbid diagnosis major depressive disorder (PD + MDD). We also sought to explore the potential contribution of cognitive variables to help differentiate between PD and PD + MDD. This was a subgroup analysis of 331 patients with PD symptoms who were included in the PsicAP clinical trial. All participants completed scales to evaluate panic, depression, somatization, cognitive and performance variables. A univariate analysis showed significant differences (p < .01) between the groups (PD vs PD + MDD) in clinical variables. Somatization was the best predictor of comorbid PD + MDD (β = .346; p < .01). Cognitive variables do not appear to play an essential role in predicting the presence of depressive symptoms in people with a screen positive for PD. These findings appear to support a transdiagnostic treatment approach for PD, which may be useful regardless of whether comorbid depression is present or not.

中文翻译：

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区分惊恐障碍伴或不伴抑郁症共病症状的因素

本研究的目的是检查可能被诊断为惊恐障碍 (PD) 的人和患有 PD 并可能合并诊断为重度抑郁症 (PD + MDD) 的人之间的社会人口学和临床差异。我们还试图探索认知变量的潜在贡献，以帮助区分 PD 和 PD + MDD。这是对 PsicAP 临床试验中 331 名具有 PD 症状的患者进行的亚组分析。所有参与者都完成了评估恐慌、抑郁、躯体化、认知和表现变量的量表。单变量分析显示 各组（PD 与 PD + MDD）之间的临床变量存在显着差异 ( p < .01)。躯体化是共病 PD + MDD 的最佳预测指标（β = .346；p < .01)。认知变量在预测 PD 筛查呈阳性的人群中是否存在抑郁症状方面似乎没有发挥重要作用。这些发现似乎支持 PD 的跨诊断治疗方法，无论是否存在共病抑郁症，这都可能有用。