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Green synthesis and properties of arginine derived complexes for assorted drug delivery systems: A review
Sustainable Chemistry and Pharmacy ( IF 5.5 ) Pub Date : 2021-05-16 , DOI: 10.1016/j.scp.2021.100441
Dinal V. Patel , Mehul N. Patel , Mansi S. Dholakia , B.N. Suhagia

In the current scenario, green technologies in chemistry and various fields create attention to every researcher. The green synthesis provides environmentally and eco-friendly raw materials and intermediate products, making a simple process without using harmful and toxic reactants. Amino acids are one of the reactants from which the intermediates or excipients can be made using the straightforward methodology, and these are utilized in drug delivery via a different route of Administration. By employing such medication at a cellular level, we can eliminate the adverse events and toxicity of chemically synthesized excipients and achieve a better therapeutic effect. In the present paper, Arginine was reviewed as the starting material from which the greener excipients can be synthesized, and these materials were employed for drug delivery systems. However, some of the synthetic processes employed chemicals, and also usage of the synthesized green material in the formulation of different dosage forms may require proper guidelines, but still, the research is going on for the application of green excipients for therapeutic purposes. Moreover, Arginine, as such, is an amino acid. It can also be utilized in different formulations as an active ingredient, which was also emphasized in the review paper from past research and patents.

This review aims to be comprehensive and have general interest for chemists as it involves the various routes by which excipients were synthesized and the study, including the properties of different excipients and their application.



中文翻译:

用于各种药物递送系统的精氨酸衍生复合物的绿色合成和性质:综述

在当前情况下,化学和各个领域的绿色技术引起了每位研究者的注意。绿色合成提供了环境和生态友好的原材料和中间产品,使过程简单而无需使用有害和有毒的反应物。氨基酸是可以使用简单方法从中制备中间体或赋形剂的反应物之一,并且这些氨基酸可通过不同的给药途径用于药物输送。通过在细胞水平上使用这种药物,我们可以消除化学合成的赋形剂的不良反应和毒性,并获得更好的治疗效果。在本文中,将精氨酸作为可以合成绿色赋形剂的原料进行了综述,并将这些材料用于药物递送系统。然而,某些合成方法使用化学药品,并且合成的绿色材料在不同剂型的制剂中的使用可能需要适当的指导原则,但是,仍在继续研究将绿色赋形剂用于治疗目的。此外,精氨酸本身就是氨基酸。它也可以作为有效成分用于不同的制剂中,过去的研究和专利在评论文件中也强调了这一点。

这篇综述旨在使化学家具有广泛的兴趣和广泛的兴趣,因为它涉及合成辅料和研究的各种途径,包括不同辅料的性质及其应用。

更新日期:2021-05-17
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