Preparation of oleic acid–carboxymethylcellulose sodium composite vesicle and its application in encapsulating nicotinamide,Polymer International

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Preparation of oleic acid–carboxymethylcellulose sodium composite vesicle and its application in encapsulating nicotinamide
Polymer International ( IF 2.9 ) Pub Date : 2021-05-16 , DOI: 10.1002/pi.6256
Xiangnan Guo ₁ , Jisheng Yang ₁

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Fatty acid vesicles are a kind of natural biological material, which have the advantages of good biocompatibility, low cost and easy self-assembly in aqueous solution. However, vesicles formed of fatty acids have weak pH stability and thermostability, and poor divalent salt resistance, which limit their applications. In this work, the anionic surfactant sodium oleate and the polysaccharide carboxymethylcellulose sodium were mixed to form composite vesicles in a wide pH range, which can be close to the pH range of the physiological environment. The morphology of the composite vesicles was characterized using transmission electron microscopy and the particle size was determined by dynamic light scattering. Forces and aggregation behavior in the formation of the composite vesicles were investigated using surface tension and Fourier transform infrared observations combined with turbidity measurements. The composite vesicles were used to encapsulate nicotinamide. The encapsulation efficiency and sustained release behavior of nicotinamide loaded in the composite vesicles were evaluated. These results can provide theoretical guidance for the application of drug-loaded vesicles in cosmetics. © 2021 Society of Industrial Chemistry.

中文翻译：

油酸-羧甲基纤维素钠复合囊泡的制备及其在包封烟酰胺中的应用

脂肪酸囊泡是一种天然生物材料，具有生物相容性好、成本低、易在水溶液中自组装等优点。然而，由脂肪酸形成的囊泡的pH稳定性和热稳定性较差，耐二价盐性差，限制了其应用。本工作将阴离子表面活性剂油酸钠与多糖羧甲基纤维素钠混合形成复合囊泡，pH范围较宽，可接近生理环境的pH范围。使用透射电子显微镜表征复合囊泡的形态，并通过动态光散射测定粒径。使用表面张力和傅立叶变换红外观察结合浊度测量研究复合囊泡形成过程中的力和聚集行为。复合囊泡用于封装烟酰胺。评估了负载在复合囊泡中的烟酰胺的包封效率和缓释行为。这些结果可为载药囊泡在化妆品中的应用提供理论指导。© 2021 工业化学学会。这些结果可为载药囊泡在化妆品中的应用提供理论指导。© 2021 工业化学学会。这些结果可为载药囊泡在化妆品中的应用提供理论指导。© 2021 工业化学学会。

更新日期：2021-05-16

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