Non-shivering thermogenesis takes place in brown and beige adipocytes and facilitates cold tolerance and acclimation. However, thermogenesis in adipose tissue also was found to be activated in metabolic overload states for fast utilization of nutrients excess. This observation spurred research interest in mechanisms of thermogenesis regulation for metabolic overload and obesity prevention. One of proposed regulators of thermogenic efficiency in adipocytes is the dynamics of mitochondria, where thermogenesis takes place. Indeed, brown and beige adipocytes exhibit fragmented round-shaped mitochondria, while white adipocytes have elongated organelles with high ATP synthesis. Mitochondrial morphology can determine uncoupling protein 1 (UCP1) content, efficiency of catabolic pathways and electron transport chain, supplying thermogenesis. This review will highlight the co-regulation of mitochondrial dynamics and thermogenesis and formulate hypothetical ways for excessive nutrients burning in response to mitochondrial morphology manipulation.

不颤抖的产热发生在棕色和米色的脂肪细胞中，有助于耐寒和适应。然而，脂肪组织中的产热也被发现在代谢超负荷状态下被激活，以快速利用过量的营养物质。这一观察结果激发了人们对代谢超负荷和肥胖预防的产热调节机制的研究兴趣。建议的脂肪细胞产热效率调节因子之一是线粒体的动力学，其中发生产热。事实上，棕色和米色的脂肪细胞表现出碎片化的圆形线粒体，而白色脂肪细胞具有细长的细胞器，具有高 ATP 合成。线粒体形态可以确定解偶联蛋白 1 (UCP1) 含量、分解代谢途径和电子传递链的效率，提供产热。