Herbicides reduce the unsafe effects of weeds, but they are likely to have negative impact on essential and secondary metabolism in crops. However, the combined effect of different herbicides on chemical constituents of different varieties of wheat is still not fully obvious. The current investigation was carried out to determine the effects of three post-emergence herbicides (pinoxaden, tribenuron-methyl, and pyroxsulam) on total protein, lipid, and carbohydrate concentrations of three bread wheat cultivars (Misr 1, Giza 171, and Gemmiza 11). These herbicides were added individually and in combinations at recommended and/or half recommended doses. Our findings revealed that the individual application of herbicides decreased total protein and total lipid concentrations in fresh shoots of the three studied wheat cultivars, but increased total carbohydrate concentration. Combined addition of herbicides at recommended and half recommended doses generally decreased the concentrations of total proteins, total lipids, and total carbohydrates. However, the combined addition of tribenuron-methyl and pinoxaden at recommended dose enhanced total protein and total lipid concentrations under Misr1 and Gemmiza 11 cultivars compared to control treatment. Furthermore, the combined addition of tribenuron-methyl and pyroxsulam at half recommended dose enhanced total protein concentration in Giza 171 up to 15.05% and Gemmiza 11 up to 15.09% cultivars, and total lipid concentration in Misr 1 (7.53%) and Giza 171 (9.81%) cultivars against control treatment, where it was the lowest. Total carbohydrate concentration was enhanced by the sole application of pinoxaden by 53.55%, 52.40%, and 51.79% for Misr 1, Giza 171, and Gemmiza 11 cultivars, respectively. Moreover, individual or combined additions of the studied pesticides at recommended and half recommended doses negatively affected wheat grains under all cultivars via decreasing their concentration of nutrients (nitrogen, phosphorus, and potassium) as well as total protein and total carbohydrates. The highest reduction of nitrogen, phosphorus, and potassium concentrations compared to control was observed when tribenuron-methyl+pyroxsulam was applied at the half recommended dose under the three studied cultivars. However, the combined application of tribenuron-methyl+pyroxsulam at the half recommended dose caused the great depression in total proteins and total carbohydrates of wheat grains. Under the stress effect of herbicides, individual application of pinoxaden gave the best results for nitrogen and potassium content as well as total protein and total carbohydrate concentrations in the three studied wheat grain cultivars.

除草剂减少了杂草的不安全影响，但它们可能对作物的基本和次生代谢产生负面影响。然而，不同除草剂对不同品种小麦化学成分的综合作用尚不十分明显。目前的调查是为了确定三种芽后除草剂（吡诺沙登、苯磺隆和吡磺草胺）对三种面包小麦品种（Misr 1、Giza 171 和 Gemmiza 11）的总蛋白质、脂质和碳水化合物浓度的影响）。这些除草剂以推荐和/或推荐剂量的一半单独和组合添加。我们的研究结果表明，单独施用除草剂降低了三个研究小麦品种的新鲜枝条中的总蛋白质和总脂质浓度，但增加了总碳水化合物浓度。以推荐剂量和一半推荐剂量联合添加除草剂通常会降低总蛋白质、总脂质和总碳水化合物的浓度。然而，与对照处理相比，在 Misr1 和 Gemmiza 11 品种下，以推荐剂量联合添加苯磺隆和吡诺沙登可提高总蛋白和总脂质浓度。此外，以推荐剂量的一半联合添加苯磺隆和吡磺草胺使 Giza 171 和 Gemmiza 11 的总蛋白质浓度提高了 15.05%，Gemmiza 11 的总蛋白质浓度提高了 15.09%，Misr 1（7.53%）和 Giza 171 的总脂质浓度提高了（ 9.81%) 栽培品种对抗对照处理，其最低。单独使用吡诺沙登可将总碳水化合物浓度提高 53.55%、52.40%、Misr 1、Giza 171 和 Gemmiza 11 品种分别为 51.79% 和 51.79%。此外，以推荐剂量和一半推荐剂量单独或组合添加所研究的杀虫剂，通过降低营养成分（氮、磷和钾）以及总蛋白质和总碳水化合物的浓度，对所有品种的小麦籽粒产生负面影响。在三个研究的栽培品种中，当以推荐剂量的一半施用苯磺隆+甲基磺草胺时，观察到与对照相比氮、磷和钾浓度的降低幅度最大。然而，以推荐剂量的一半联合施用甲基苯磺隆+吡磺草胺，导致小麦籽粒总蛋白质和总碳水化合物的大幅下降。在除草剂的胁迫作用下，