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Anti-inflammatory and anti-diabetic activity of 8-Hydroxyquinolinium 3,5-Dinitrobenzoate
Chemical Data Collections Pub Date : 2021-05-15 , DOI: 10.1016/j.cdc.2021.100726
Dhurairaj Satheesh , Ragunathan Roshini , Sekar Jeevitha , Kasi Chithra , Srinivasan Vasanth Kumar , Periyasamy Sellam

An organic salt, 8-Hydroxyquinolinium 3,5-Dinitrobenzoate (8-HQH-3,5-DNB) was prepared by the simple protonation reaction of 8-Hydroxyquinoline (8-HQ) with 3,5-Dinitrobenzoic acid (DNBA). The formation of the organic salt 8-HQH-3,5-DNB was successfully confirmed by CHN elemental analysis, FT-IR and 1H NMR spectral studies. The organic salt 8-HQH-3,5-DNB was screened to its anti-inflammatory and anti-diabetic activity in different concentrations (10, 25, 50, 125 and 250 μg/mL). The 8-HQH-3,5-DNB is showing very good anti-inflammatory and anti-diabetic activities compared to the corresponding standard drug.



中文翻译:

8-羟基喹啉鎓3,5-二硝基苯甲酸酯的抗炎和抗糖尿病活性

通过8-羟基喹啉(8-HQ)与3,5-二硝基苯甲酸(DNBA)的简单质子化反应制备了有机盐8,5-二硝基苯甲酸8-羟基喹啉鎓盐(8-HQH-3,5-DNB)。通过CHN元素分析,FT-IR和1 H NMR光谱研究成功证实了有机盐8-HQH-3,5-DNB的形成。对有机盐8-HQH-3,5-DNB进行了不同浓度(10、25、50、125和250μg/ mL)的抗炎和抗糖尿病活性筛选。该8-HQH -3,5- DNB是示出相对于相应的标准药物非常良好的抗炎和抗糖尿病活性。

更新日期:2021-05-24
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