Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patients with severe tuberculosis requiring critical care admission was observed. As a first aim, we performed the analysis of the genetic structure of strains isolated from patients with severe tuberculosis admitted to an intensive care unit. We compared these results with those corresponding to the general population observing a statistically significant increase in the Haarlem genotypes among ICU patients (53.3% vs 34.7%; p < 0.05). In addition, we investigated the association of clinical outcomes with the genotype observing a major incidence of hepatic dysfunctions among patients infected with the Haarlem strain (p < 0.05). The cohort presented is one of the largest studied series of critically ill patients with tuberculosis.

人类结核病仍然是一个主要的世界健康问题。在乌拉圭，与世界趋势相反，自 2006 年以来观察到病例有所增加。尽管耐多药菌株的发病率很低，并且没有登记广泛耐药结核病病例，但需要治疗的重症结核病患者数量有所增加。观察到重症监护入院。作为第一个目标，我们分析了从重症监护病房收治的严重结核病患者中分离出的菌株的遗传结构。我们将这些结果与普通人群的结果进行了比较，观察到 ICU 患者的 Haarlem 基因型在统计学上显着增加（53.3% 对 34.7%；p  < 0.05)。此外，我们调查了临床结果与基因型之间的关系，观察到哈勒姆菌株感染患者肝功能障碍的主要发生率（p  <  0.05）。所提出的队列是对结核病危重患者进行的最大研究系列之一。