DNA Assembly-Based Stimuli-Responsive Systems,Advanced Science

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DNA Assembly-Based Stimuli-Responsive Systems
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-14 , DOI: 10.1002/advs.202100328
Shasha Lu ₁ , Jianlei Shen ₁ , Chunhai Fan _{1,

2} , Qian Li ₁ , Xiurong Yang ₁

Affiliation

Stimuli-responsive designs with exogenous stimuli enable remote and reversible control of DNA nanostructures, which break many limitations of static nanostructures and inspired development of dynamic DNA nanotechnology. Moreover, the introduction of various types of organic molecules, polymers, chemical bonds, and chemical reactions with stimuli-responsive properties development has greatly expand the application scope of dynamic DNA nanotechnology. Here, DNA assembly-based stimuli-responsive systems are reviewed, with the focus on response units and mechanisms that depend on different exogenous stimuli (DNA strand, pH, light, temperature, electricity, metal ions, etc.), and their applications in fields of nanofabrication (DNA architectures, hybrid architectures, nanomachines, and constitutional dynamic networks) and biomedical research (biosensing, bioimaging, therapeutics, and theranostics) are discussed. Finally, the opportunities and challenges for DNA assembly-based stimuli-responsive systems are overviewed and discussed.

中文翻译：

基于 DNA 组装的刺激响应系统

利用外源刺激的刺激响应设计能够实现对 DNA 纳米结构的远程和可逆控制，这打破了静态纳米结构的许多限制，并激发了动态 DNA 纳米技术的发展。而且，各类有机分子、聚合物、化学键和具有刺激响应特性的化学反应的引入，极大地拓展了动态DNA纳米技术的应用范围。本文综述了基于DNA组装的刺激响应系统，重点介绍了依赖于不同外源刺激（DNA链、pH、光、温度、电、金属离子等）的响应单元和机制，及其在生物医学中的应用。讨论了纳米制造（DNA 结构、混合结构、纳米机器和体质动态网络）和生物医学研究（生物传感、生物成像、治疗学和治疗诊断学）领域。最后，概述和讨论了基于 DNA 组装的刺激响应系统的机遇和挑战。

更新日期：2021-07-07

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