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Cortical disinhibitory circuits: cell types, connectivity and function
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2021-05-15 , DOI: 10.1016/j.tins.2021.04.009
Klas Kullander 1 , Lisa Topolnik 2
Affiliation  

The concept of a dynamic excitation/inhibition balance tuned by circuit disinhibition, which can shape information flow during complex behavioral tasks, has arisen as an important and conserved information-processing motif. In cortical circuits, different subtypes of GABAergic inhibitory interneurons are connected to each other, offering an anatomical foundation for disinhibitory processes. Moreover, a subpopulation of GABAergic cells that express vasoactive intestinal polypeptide (VIP) preferentially innervates inhibitory interneurons, highlighting their central role in disinhibitory modulation. We discuss inhibitory neuron subtypes involved in disinhibition, with a focus on local circuits and long-range synaptic connections that drive disinhibitory function. We highlight multiple layers of disinhibition across cortical circuits that regulate behavior and serve to maintain an excitation/inhibition balance.



中文翻译:

皮质去抑制回路:细胞类型、连接性和功能

由电路去抑制调节的动态激发/抑制平衡的概念可以在复杂的行为任务中塑造信息流,已成为重要且保守的信息处理主题。在皮质回路中,不同亚型的 GABA 能抑制中间神经元相互连接,为去抑制过程提供解剖学基础。此外,表达血管活性肠多肽 (VIP) 的 GABA 能细胞亚群优先支配抑制性中间神经元,突出了它们在去抑制调节中的核心作用。我们讨论了参与去抑制的抑制性神经元亚型,重点是驱动去抑制功能的局部回路和远程突触连接。

更新日期:2021-05-15
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