Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases, denoting the likely therapeutic promises for targeting ferroptosis in the preservation of human health. Ferritinophagy, a selective form of autophagy, contributes to the initiation of ferroptosis through degradation of ferritin, which triggers labile iron overload (IO), lipid peroxidation, membrane damage, and cell death. In this review, we will delineate the role of ferritinophagy in ferroptosis, and its underlying regulatory mechanisms, to unveil the therapeutic value of ferritinophagy as a target in the combat of ferroptosis to manage metabolic diseases.

Ferroptosis 是一种受调节的细胞死亡方式，与受干扰的铁稳态和不受限制的脂质过氧化有关。大量证据表明，铁死亡作为人类疾病的原因或后果发挥了重要作用，表明在保护人类健康方面可能有针对铁死亡的治疗前景。铁蛋白吞噬是自噬的一种选择性形式，通过降解铁蛋白导致铁死亡，从而引发不稳定的铁过载 (IO)、脂质过氧化、膜损伤和细胞死亡。在这篇综述中，我们将描述吞噬铁蛋白在铁死亡中的作用及其潜在的调控机制，以揭示吞噬铁蛋白作为对抗铁死亡治疗代谢疾病的靶点的治疗价值。