Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell,Journal of Natural Medicines

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Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell
Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2021-05-15 , DOI: 10.1007/s11418-021-01528-8
Takahiro Kitagawa ₁ , Takahiro Matsumoto ₁ , Daisuke Imahori ₁ , Mayuka Kobayashi ₁ , Masaya Okayama ₁ , Tomoe Ohta ₂ , Tatsusada Yoshida ₂ , Tetsushi Watanabe ₁

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From the fruits of Fortunella crassifolia and the peels of Citrus junos, two new limonoids, fortunellone and junosol were isolated together with three known compounds including nomilin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence. For fortunellone, the absolute configuration was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Fortunellon and nomilin significantly increased the number of dead cells on adriamycin (ADR)-treated human cervical cancer cells (HeLa). On the other hand, fortunellon and nomilin did not affects the number of dead cells alone. These results suggested that fortunellone and nomilin may have the potency as the chemotherapy enhancement agents.

Graphic abstract

中文翻译：

从金桔和柑橘中分离的柠檬苦素类化合物对阿霉素处理的癌细胞具有细胞死亡诱导活性

从果实金柑云杉和果皮香橙，两个新的柠檬苦素，fortunellone和junosol被连同三个已知化合物，包括诺米林隔离。基于化学/物理化学证据阐明了新化合物的化学结构。对于 Fortunellone，绝对构型是通过比较实验和预测的电子圆二色性 (ECD) 数据来建立的。Fortunellon 和 nomilin 显着增加了阿霉素 (ADR) 处理的人宫颈癌细胞 (HeLa) 上的死细胞数量。另一方面，fortunellon 和 nomilin 不会单独影响死细胞的数量。这些结果表明财富酮和诺米林可能具有作为化疗增强剂的效力。

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更新日期：2021-05-15

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