Metabolic tumour volumes (MTV) and total lesion glycolysis (TLG) are metabolic parameters that are becoming more commonly reported in human medicine to quantify tumours detected on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT). In this retrospective study dogs afflicted with appendicular osteosarcoma that were staged with ¹⁸F-FDG PET/CT had MTV and TLG at a variety of set and fixed thresholds calculated by two observers. These values, along with SUV_max, were evaluated for prognostic significance in this population of dogs. There was excellent correlation between two observers for all values. Multiple volumetric parameters were significantly associated with survival. SUV_max had the highest sensitivity for survival and TLG at 2.5 SUV*cm³ had the highest specificity for prediction of survival based on ROC calculations. The SUV_max, MTV at 2.5 SUV and TLG at 2.5 SUV*cm³ were significantly different between dogs that survived more than or less than 1 year. This study is the first of its kind in veterinary medicine that retrospectively evaluated volumetric tumour values for prognostic significance and may provide a basis for standardized method of reporting ¹⁸F-FDG PET/CT results.

中文翻译：

---

氟-18 氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描对犬分期阑尾骨肉瘤的代谢肿瘤体积和总病灶糖酵解的预后意义

代谢性肿瘤体积 (MTV) 和总病灶糖酵解 (TLG) 是人类医学中越来越常见的代谢参数，用于量化氟-18 氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描 ( ¹⁸ F-FDG PET/CT) 检测到的肿瘤。在这项回顾性研究中，患有阑尾骨肉瘤的狗用¹⁸ F-FDG PET/CT 分期，其 MTV 和 TLG 处于由两名观察者计算的各种设定和固定阈值。这些值与 SUV _max一起评估了该犬群的预后意义。对于所有值，两个观察者之间存在极好的相关性。多个体积参数与生存率显着相关。_最大SUV根据 ROC 计算，2.5 SUV*cm ^{3处的 TLG 对生存的敏感性最高，TLG 对生存预测的特异性最高。}存活超过或少于 1 年的狗的 SUV _max、2.5 SUV 的 MTV 和 2.5 SUV*cm ^{3的 TLG 显着不同。}这项研究是兽医学中第一个回顾性评估体积肿瘤值的预后意义的研究，可能为报告¹⁸ F-FDG PET/CT 结果的标准化方法提供基础。