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68Ga-DOTATOC-PET/MRI and 11C-5-HTP-PET/MRI are superior to 68Ga-DOTATOC-PET/CT for neuroendocrine tumour imaging
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2021-05-14 , DOI: 10.1111/jne.12981 Hiba Jawlakh 1 , Irina Velikyan 1 , Staffan Welin 2 , Anders Sundin 1
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2021-05-14 , DOI: 10.1111/jne.12981 Hiba Jawlakh 1 , Irina Velikyan 1 , Staffan Welin 2 , Anders Sundin 1
Affiliation
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The present study aimed to assess gadoxetate disodium contrast-enhanced (CE) positron emission tomography (PET)/magnetic resonance imaging (MRI) with 68Ga-DOTATOC and 11C-5-Hydroxy-tryptophan (11C-5-HTP) in comparison with iodine CE 68Ga-DOTATOC-PET/computed tomography (CT) for neuroendocrine tumour imaging. Detection rate and reader's confidence were evaluated for each separate image volume: CE-CT, CE-MRI including diffusion-weighted imaging, 68Ga-DOTATOC-PET performed at PET/CT, 68Ga-DOTATOC-PET performed at PET/MRI and 11C-5-HTP-PET, and for the three combined hybrid examinations 68Ga-DOTATOC-PET/MRI, 11C-5-HTP-PET/MRI and 68Ga-DOTATOC-PET/CT. In 11 patients, 255 lesions were depicted. 68Ga-DOTATOC-PET performed at PET/MRI depicted 72.5%, 68Ga-DOTATOC-PET performed at PET/CT depicted 62.7%, 11C-5-HTP-PET depicted 68.2% and CE-CT depicted 53% of lesions. 68Ga-DOTATOC-PET performed at PET/MRI (P < 0.001) and PET/CT (P = 0.02), 11C-5-HTP-PET (P < 0.001) and MRI (P < 0.001) were superior to CT. 68Ga-DOTATOC-PET/MRI and 11C-5-HTP-PET/MRI detected 92.5% and 92% of lesions, respectively, and both outperformed 68Ga-DOTATOC-PET/CT (65%) (P < 0.001). For liver metastasis imaging, MRI alone was unsurpassed (P < 0.01) and 68Ga-DOTATOC-PET/MRI and 11C-5-HTP-PET/MRI outperformed 68Ga-DOTATOC-PET/CT (P < 0.001). For lymph node metastasis diagnosis, 68Ga-DOTATOC-PET performed at PET/MRI and PET/CT and 11C-5-HTP-PET detected 94%, 94% and 94% of lesions, respectively, and outperformed MRI and CE-CT alone (P < 0.001). For bone metastasis imaging, 68Ga-DOTATOC-PET performed at PET/MRI and PET/CT and 11C-5-HTP-PET performed equally well (P = 0.05) and better than MRI. Reader's confidence was better for 68Ga-DOTATOC-PET/MRI and 11C-5-HTP-PET/MRI than for 68Ga-DOTATOC-PET/CT. The tumour maximum standardised uptake value and tumour-to-liver ratio were both approximately twice as high as for 68Ga-DOTATOC than for 11C-5-HTP. 68Ga-DOTATOC-PET/MRI and 11C-5-HTP-PET/MRI provided the highest detection rates and reader's confidence and were both superior to 68Ga-DOTATOC-PET/CT, mainly because of the MRI component. The imaging contrast with 68Ga-DOTATOC was superior to that of 11C-5-HTP.
中文翻译：
68Ga-DOTATOC-PET/MRI和11C-5-HTP-PET/MRI在神经内分泌肿瘤成像方面优于68Ga-DOTATOC-PET/CT
本研究旨在评估使用68 Ga-DOTATOC 和11 C-5-羟基色氨酸 ( 11 C-5-HTP) 的钆塞酸二钠对比增强 (CE) 正电子发射断层扫描 (PET)/磁共振成像 (MRI)与碘 CE 68 Ga-DOTATOC-PET/计算机断层扫描 (CT) 神经内分泌肿瘤成像的比较。对每个单独图像体积的检出率和读者置信度进行了评估：CE-CT、CE-MRI（包括扩散加权成像）、在 PET/CT 中执行的68 Ga-DOTATOC-PET、在 PET/MRI 中执行的68 Ga-DOTATOC-PET 和11 C-5-HTP-PET，以及三种组合混合检查68 Ga-DOTATOC-PET/MRI、 11 C-5-HTP-PET/MRI 和68 Ga-DOTATOC-PET/CT。在 11 名患者中，描绘了 255 个病变。在 PET/MRI 上进行的68 Ga-DOTATOC-PET 描绘了 72.5%，在 PET/CT 上进行的68 Ga-DOTATOC-PET 描绘了 62.7%， 11 C-5-HTP-PET 描绘了 68.2%，CE-CT 描绘了 53% 的病变。 68 Ga-DOTATOC-PET 在 PET/MRI ( P < 0.001) 和 PET/CT ( P = 0.02)、 11 C-5-HTP-PET ( P < 0.001) 和 MRI ( P < 0.001) 上均优于 CT 。 68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 分别检出 92.5% 和 92% 的病灶，均优于68 Ga-DOTATOC-PET/CT (65%) ( P < 0.001) 。对于肝转移成像，单独 MRI 的表现无与伦比 ( P < 0.01)， 68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 优于68 Ga-DOTATOC-PET/CT ( P < 0.001)。 对于淋巴结转移诊断，在 PET/MRI 和 PET/CT 中进行的68 Ga-DOTATOC-PET 和11 C-5-HTP-PET 分别检测出 94%、94% 和 94% 的病灶，并且优于 MRI 和 CE-单独 CT（ P < 0.001）。对于骨转移成像，在 PET/MRI 和 PET/CT 中进行的68 Ga-DOTATOC-PET 和11 C-5-HTP-PET 表现同样好（ P = 0.05）并且优于 MRI。读者对68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 的信心高于68 Ga-DOTATOC-PET/CT。 68 Ga-DOTATOC 的肿瘤最大标准化摄取值和肿瘤与肝脏的比率均比11 C-5-HTP 高约两倍。 68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 提供了最高的检出率和读者置信度，并且均优于68 Ga-DOTATOC-PET/CT，主要是因为 MRI 成分。 68 Ga-DOTATOC 的成像对比度优于11 C-5-HTP。
更新日期：2021-06-11
中文翻译：
68Ga-DOTATOC-PET/MRI和11C-5-HTP-PET/MRI在神经内分泌肿瘤成像方面优于68Ga-DOTATOC-PET/CT
本研究旨在评估使用68 Ga-DOTATOC 和11 C-5-羟基色氨酸 ( 11 C-5-HTP) 的钆塞酸二钠对比增强 (CE) 正电子发射断层扫描 (PET)/磁共振成像 (MRI)与碘 CE 68 Ga-DOTATOC-PET/计算机断层扫描 (CT) 神经内分泌肿瘤成像的比较。对每个单独图像体积的检出率和读者置信度进行了评估：CE-CT、CE-MRI（包括扩散加权成像）、在 PET/CT 中执行的68 Ga-DOTATOC-PET、在 PET/MRI 中执行的68 Ga-DOTATOC-PET 和11 C-5-HTP-PET，以及三种组合混合检查68 Ga-DOTATOC-PET/MRI、 11 C-5-HTP-PET/MRI 和68 Ga-DOTATOC-PET/CT。在 11 名患者中，描绘了 255 个病变。在 PET/MRI 上进行的68 Ga-DOTATOC-PET 描绘了 72.5%，在 PET/CT 上进行的68 Ga-DOTATOC-PET 描绘了 62.7%， 11 C-5-HTP-PET 描绘了 68.2%，CE-CT 描绘了 53% 的病变。 68 Ga-DOTATOC-PET 在 PET/MRI ( P < 0.001) 和 PET/CT ( P = 0.02)、 11 C-5-HTP-PET ( P < 0.001) 和 MRI ( P < 0.001) 上均优于 CT 。 68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 分别检出 92.5% 和 92% 的病灶，均优于68 Ga-DOTATOC-PET/CT (65%) ( P < 0.001) 。对于肝转移成像，单独 MRI 的表现无与伦比 ( P < 0.01)， 68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 优于68 Ga-DOTATOC-PET/CT ( P < 0.001)。 对于淋巴结转移诊断，在 PET/MRI 和 PET/CT 中进行的68 Ga-DOTATOC-PET 和11 C-5-HTP-PET 分别检测出 94%、94% 和 94% 的病灶，并且优于 MRI 和 CE-单独 CT（ P < 0.001）。对于骨转移成像，在 PET/MRI 和 PET/CT 中进行的68 Ga-DOTATOC-PET 和11 C-5-HTP-PET 表现同样好（ P = 0.05）并且优于 MRI。读者对68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 的信心高于68 Ga-DOTATOC-PET/CT。 68 Ga-DOTATOC 的肿瘤最大标准化摄取值和肿瘤与肝脏的比率均比11 C-5-HTP 高约两倍。 68 Ga-DOTATOC-PET/MRI 和11 C-5-HTP-PET/MRI 提供了最高的检出率和读者置信度，并且均优于68 Ga-DOTATOC-PET/CT，主要是因为 MRI 成分。 68 Ga-DOTATOC 的成像对比度优于11 C-5-HTP。
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