Although it is known that health is not merely the absence of disease, the positive aspects of mental health have been less comprehensively researched compared with its negative aspects. Subjective well-being (SWB) is one of the indicators of positive psychology, and high SWB is considered to benefit individuals in multiple ways. However, the neural mechanisms underlying individual differences in SWB remain unclear, particularly in terms of brain microstructural properties as detected by diffusion tensor imaging. The present study aimed to investigate the relationship between measurements of diffusion tensor imaging [mean diffusivity (MD) and fractional anisotropy] and the degree of SWB as measured using a questionnaire. Voxel-based analysis was used to investigate the association between MD and SWB scores in healthy young adults (age, 20.7 ± 1.8 years; 695 males and 514 females). Higher levels of SWB were found to be associated with lower MD in areas surrounding the right putamen, insula, globus pallidus, thalamus and caudate. These results indicated that individual SWB is associated with variability in brain microstructural properties.

中文翻译：

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与主观幸福感相关的脑微结构特性：扩散张量成像分析

虽然众所周知，健康不仅仅是没有疾病，但与其消极方面相比，对心理健康积极方面的研究还不够全面。主观幸福感 (SWB) 是积极心理学的指标之一，高 SWB 被认为对个人有多种好处。然而，SWB 个体差异背后的神经机制仍不清楚，特别是在扩散张量成像检测到的脑微结构特性方面。本研究旨在调查扩散张量成像测量[平均扩散率 (MD) 和分数各向异性] 与使用问卷测量的 SWB 程度之间的关系。基于体素的分析用于研究健康年轻人（年龄为 20.7 ± 1. 8年; 695 名男性和 514 名女性）。发现较高水平的 SWB 与右壳核、岛叶、苍白球、丘脑和尾状核周围区域的较低 MD 相关。这些结果表明，个体 SWB 与脑微结构特性的可变性有关。