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Simple amino silyl ether organocatalyst for asymmetric hetero Diels–Alder reaction of isatins with enones
Chirality ( IF 2.8 ) Pub Date : 2021-05-13 , DOI: 10.1002/chir.23319 Perumalsamy Parasuraman 1 , Divakar Ganesan 1 , Zubeda Begum 1 , Chigusa Seki 1 , Yuko Okuyama 2 , Eunsang Kwon 3 , Koji Uwai 1 , Michio Tokiwa 4 , Suguru Tokiwa 4 , Mitsuhiro Takeshita 4 , Hiroto Nakano 1
Chirality ( IF 2.8 ) Pub Date : 2021-05-13 , DOI: 10.1002/chir.23319 Perumalsamy Parasuraman 1 , Divakar Ganesan 1 , Zubeda Begum 1 , Chigusa Seki 1 , Yuko Okuyama 2 , Eunsang Kwon 3 , Koji Uwai 1 , Michio Tokiwa 4 , Suguru Tokiwa 4 , Mitsuhiro Takeshita 4 , Hiroto Nakano 1
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New two catalysts component system comprising of a primary β-amino silyl ethers as an organocatalyst and N-protected amino acids as a co-catalyst put together worked as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones affording the chiral spirooxindole-tetrahydropyranones in good chemical yields and stereoselectivities (up to 94%, up to dr 78:22., up to 85% ee).
中文翻译：
用于靛红与烯酮的不对称杂 Diels-Alder 反应的简单氨基甲硅烷基醚有机催化剂
新的两种催化剂组分系统由作为有机催化剂的伯 β-氨基甲硅烷基醚和作为助催化剂的N-保护氨基酸组合在一起，在靛红与烯酮的杂 Diels-Alder 反应中作为有效的有机催化剂系统发挥作用，提供手性spirooxindole-tetrahydropyranones在良好的化学产率和立体选择性（高达94％，高达博士78:22。，高达85％的ee值）。
更新日期：2021-07-16
中文翻译：
用于靛红与烯酮的不对称杂 Diels-Alder 反应的简单氨基甲硅烷基醚有机催化剂
新的两种催化剂组分系统由作为有机催化剂的伯 β-氨基甲硅烷基醚和作为助催化剂的N-保护氨基酸组合在一起，在靛红与烯酮的杂 Diels-Alder 反应中作为有效的有机催化剂系统发挥作用，提供手性spirooxindole-tetrahydropyranones在良好的化学产率和立体选择性（高达94％，高达博士78:22。，高达85％的ee值）。
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