Abstract—

The review considers complex, controversial, and individual effects of heparin and its derivatives on the bone and circulatory systems in dependence of the dose, the state of the cells and tissues of the recipient. General data on the anticoagulant activity of heparin and its derivatives are presented; special attention is paid to the effect of heparin on mesenchymal cells and tissues and its role in angiogenesis. We also discuss the ability of heparin to bind osteogenic and angiogenic biomolecules in the context of the development of systems for their delivery and sustained controlled release and propose a schematic representation of the positive and side effects of heparin as a delivery system for biomolecules in tissue engineering.

中文翻译：

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肝素的成骨和血管生成特性作为用于骨生物工程的生物分子传递系统：简要的评论。

摘要—

该评价考虑了肝素及其衍生物对骨骼和循环系统的复杂，有争议的个体作用，具体取决于剂量，受体细胞和组织的状态。提供了有关肝素及其衍生物的抗凝活性的一般数据；特别注意肝素对间充质细胞和组织的作用及其在血管生成中的作用。我们还讨论了肝素结合其成骨和血管生成生物分子的能力，以及其递送和持续控释系统的发展情况，并提出了肝素作为组织工程中生物分子的递送系统的正面和副作用的示意图。 。