Cancer progression as a sequence of atavistic reversions,BioEssays

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Cancer progression as a sequence of atavistic reversions
BioEssays ( IF 3.2 ) Pub Date : 2021-05-13 , DOI: 10.1002/bies.202000305
Charles H Lineweaver _{1,

2} , Kimberly J Bussey _{3,

4} , Anneke C Blackburn ₅ , Paul C W Davies ₃

Affiliation

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi-unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular-to-unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one-off multicellular-to-unicellular reversion, and are better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular-eukaryote-to-multicellular-eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ

中文翻译：

癌症进展作为一系列返祖逆转

人们早就认识到，癌症的发作和进展代表了一种向祖传准单细胞表型的逆转。这一一般概念已被细化为癌症的返祖模型，该模型试图提供基于基因组数据的定量分析和可测试的预测。在过去的十年中，对返祖模型预测的多细胞到单细胞逆转的支持来自植物地层学。在这里，我们提出癌症的发作和进展不仅仅涉及一次性的多细胞到单细胞的逆转，而是更好地描述为一系列的逆转转变。我们根据单细胞-真核生物-多细胞-真核生物转变的年表做出新的预测。我们还根据我们血统中发生的其他三个进化转变做出新的预测：真核发生、氧化磷酸化和向适应性免疫的转变。我们建议对当前的植物地层学进行一些修改，以提高年龄分辨率以测试这些预测。另请参阅此处的视频摘要：https://youtu.be/3unEu5JYJrQ

更新日期：2021-06-20

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