Health literacy is the ability to deal with information related to one’s health. Patients with low health literacy and chronic diseases, such as chronic kidney disease (CKD), have poor disease-management skills, which could lead to complications. We used logistic regressions and structural equational modeling to assess whether low health literacy is associated with the development of cardiovascular disease and mortality in patients with CKD, and whether this association is mediated by the presence of uncontrolled hypertension, diabetes, dyslipidemia, obesity, or albuminuria. Data from 2742 adult participants with CKD from the Lifelines study were analyzed at baseline and after approximately four years. Low health literacy was associated with cardiovascular disease and mortality in the crude models, with OR and 95%CI of 1.93 (1.46 to 2.55) and 1.59 (1.08 to 2.36), respectively. After adjustment for age and sex, low health literacy was only associated with cardiovascular disease (OR 1.76 (1.31 to 2.23)). This association was mediated by uncontrolled diabetes (27.1%) and obesity (8.0%). Low health literacy is associated with the development of cardiovascular disease after adjustment for age and sex, and this association is mediated by uncontrolled diabetes and obesity.

中文翻译：

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不受控制的高血压，糖尿病，血脂异常和肥胖症是否介导健康素养与慢性肾脏病并发症之间的关系？

健康素养是处理与一个人的健康有关的信息的能力。健康素养低和慢性病（例如慢性肾脏病（CKD））的患者疾病管理技能差，可能导致并发症。我们使用逻辑回归和结构方程模型来评估低健康素养是否与CKD患者的心血管疾病的发展和死亡率相关，以及这种相关性是否由不受控制的高血压，糖尿病，血脂异常，肥胖或蛋白尿的存在所介导。 。在基线和大约四年后，对来自Lifelines研究的2742名CKD成人参与者的数据进行了分析。在原始模型中，健康素养低与心血管疾病和死亡率有关，OR和95％CI为1.93（1.46至2.55）和1。59（1.08至2.36）。在调整了年龄和性别之后，低健康素养仅与心血管疾病有关（OR 1.76（1.31至2.23））。这种联系是由不受控制的糖尿病（27.1％）和肥胖症（8.0％）介导的。健康素养低与年龄和性别调整后与心血管疾病的发展有关，并且这种联系是由不受控制的糖尿病和肥胖症引起的。